Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients.
Steven T. DeKosky,Patrick M. Kochanek,Alex B. Valadka,Robert S. B. Clark,Sherry H.-Y. Chou,Alicia K. Au,Christopher M. Horvat,Ruchira M. Jha,Rebekah Mannix,Stephen R. Wisniewski,Max Wintermark,Susan E. Rowell,Robert D. Welch,Lawrence M. Lewis,Stacey L. House,Rudolph E. Tanzi,Darci R. Smith,Amy Y. Vittor,Nancy D. Denslow,Michael D. Davis,Olena Glushakova,Ronald L. Hayes +21 more
TL;DR: The rationale for the use of blood biomarkers (BBs) for diagnosis of brain injury in COVID-19 patients, the research needed to incorporate their use into clinical practice, and the improvements in patient management and outcomes that can result are outlined.
Journal ArticleDOI
Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series.
Ashkan Mowla,Banafsheh Shakibajahromi,Shima Shahjouei,Afshin Borhani-Haghighi,Nasrin Rahimian,Humain Baharvahdat,Soheil Naderi,Fariborz Khorvash,Davar Altafi,Seyed Amir Ebrahimzadeh,Ghasem Farahmand,Alaleh Vaghefi Far,Vijay Sharma,Saeideh Aghayari Sheikh Neshin,Georgios Tsivgoulis,Ramin Zand,Ramin Zand +16 more
TL;DR: It is suggested that compared to non-SARS-CoV-2 infected patients, CVST occurs in older patients, with lower rates of known CVST risk factors and might lead to a poorer outcome in the SARS- CoV- 2 infected group.
Journal ArticleDOI
Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.
Nathan G. Lawler,Nicola Gray,Torben Kimhofer,Berin A. Boughton,Rongchang Yang,Aude-Claire Morillon,Sung Tong Chin,Monique Ryan,Sofina Begum,Sofina Begum,Sze-How Bong,Jerome D Coudert,Dale W. Edgar,Edward Raby,Sven Pettersson,Toby Richards,Elaine Holmes,Elaine Holmes,Luke Whiley,Jeremy K. Nicholson,Jeremy K. Nicholson,Jeremy K. Nicholson +21 more
TL;DR: In this article, the authors performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) (n = 10) or SARS CoV2 (-)(n = 49).
Journal ArticleDOI
Acute Cerebrovascular Events With COVID-19 Infection.
Mandip S. Dhamoon,Alison Thaler,Kapil Gururangan,Amit Kohli,Daniella Sisniega,Danielle Wheelwright,Connor Mensching,Johanna T Fifi,Michael G Fara,Nathalie Jette,Ella Cohen,Priya Dave,Aislyn C. DiRisio,Jonathan Goldstein,Emma M. Loebel,Naomi Mayman,Akarsh Sharma,Daniel S. Thomas,Ruben D. Vega Perez,Mark Weingarten,Huei Hsun Wen,Stanley Tuhrim,Laura K. Stein +22 more
TL;DR: Baseline characteristics in patients with stroke were similar comparing those with and without COVID-19, however, CO VID-19-positive patients were more likely to experience stroke in a lobar location, more commonly had a cryptogenic cause, and had worse outcomes.
Journal ArticleDOI
Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings.
Juan I. Guerrero,Luis A. Barragán,Juan D. Martínez,Juan P. Montoya,Alejandra Peña,Fidel Sobrino,Zulma Tovar-Spinoza,Kemel A. Ghotme +7 more
TL;DR: The evidence synthesis led to a categorical analysis of the central and peripheral involvement by COVID-19 and provided a comprehensive explanation of the reported pathophysiological mechanisms by which SARS-CoV-2 infection may cause neurological impairment.
References
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Journal ArticleDOI
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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