Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Journal ArticleDOI
COVID-19 Ischemic Strokes as an Emerging Rehabilitation Population: A Case Series.
TL;DR: Four cases of coronavirus disease 2019 ischemic strokes occurring in patients aged 37–68 yrs with varying coronav virus disease 2019 infection severities, premorbid risk factors, clinical presentations (eg, focal and nonfocal), and vascular distributions are presented.
Journal ArticleDOI
Disorders of Consciousness in Hospitalized Patients with COVID-19: The Role of the Systemic Inflammatory Response Syndrome.
Amelia K. Boehme,Kevin Doyle,Kiran T. Thakur,David Roh,Soojin Park,Sachin Agarwal,Angela Velazquez,Jennifer A Egbebike,Caroline Der Nigoghossian,Morgan L. Prust,Jon Rosenberg,Daniel Brodie,Katherine N Fishkoff,Beth R Hochmann,Leroy E Rabani,Natalie H Yip,Oliver Panzer,Jan Claassen +17 more
TL;DR: In this article, the Glasgow Coma Scale and systemic inflammatory response syndrome (SIRS) scores of patients with COVID-19 were used to determine the risk of SIRS score elevation to precede coma.
Journal ArticleDOI
Multiple embolic stroke on magnetic resonance imaging of the brain in a COVID-19 case with persistent encephalopathy.
TL;DR: A case of multifocal ischemic stroke in a patient with COVID-19, which had persistent encephalopathy and dysarthria after recovering from hypoxic respiratory failure and subsequently developed ischeMIC stroke in multiple vascular territories during hospital admission is presented.
Journal ArticleDOI
Impact of COVID-19 Pandemic on a Regional Stroke Thrombectomy Service in the United Kingdom.
Joseph Kwan,Madison Brown,Paul Bentley,Zoe Brown,Lucio D'Anna,Charles Hall,Omid Halse,Sohaa Jamil,Harri Jenkins,Dheeraj Kalladka,Maneesh C. Patel,Neil Rane,Abhinav Kumar Singh,Eleanor Taylor,Marius Venter,Lobotesis,Soma Banerjee +16 more
TL;DR: The COVID-19 pandemic has had a negative impact on the stroke admission numbers but not stroke thrombectomy rate, successful recanalization rate, or early neurological outcome.
Posted ContentDOI
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil Extracellular Traps as mediators of thrombosis in COVID-19
Jun Ding,David Earl Hostallero,Mohamed Reda El Khili,Gregory J. Fonseca,Simon Millette,Nuzha Noorah,Myriam Guay-Belzile,Jonathan Spicer,Noriko Daneshtalab,Martin G. Sirois,Karine Tremblay,Amin Emad,Simon Rousseau +12 more
TL;DR: The hypothesis that genes causing primary HLH regulate pathways linking pulmonary thromboembolism to the presence of SARS-CoV-2 is tested and the identification of Neutrophils Extracellular Traps (NETs) as plausible mediators of vascular thrombosis in severe COVID-19 in children and adults is identified.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
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COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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