Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
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COVID-19 in Kidney Transplantation: Outcomes, Immunosuppression Management, and Operational Challenges.
TL;DR: This review summarizes the published COVID-19 literature as it relates to outcomes and immunosuppression management in kidney transplant recipients and discusses challenges pertaining to pre-transplant evaluation and wait-listed patients.
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Severe COVID-19 is associated with hyperactivation of the alternative complement pathway
TL;DR: In this article , the contribution of complement pathways at both the protein and transcriptomic levels was investigated for severe coronavirus disease 2019 (COVID-19) and the role of the alternative pathway in triggering and maintaining the inflammatory state was investigated.
Journal ArticleDOI
Intracranial hemorrhage in critically ill patients hospitalized for COVID-19.
TL;DR: In this article, the authors reported three cases of spontaneous intracranial hemorrhage in patients who were initially hospitalized at a tertiary care center in Washington, DC with symptoms of COVID-19.
Journal ArticleDOI
Observational cohort study of neurological involvement among patients with SARS-CoV-2 infection
Michael Fleischer,Martin Köhrmann,Sebastian Dolff,Fabian Szepanowski,Karsten Schmidt,Frank Herbstreit,Cansu Güngör,Benjamin Stolte,Katharina M Steiner,Christine Stadtler,Joachim Riße,Melanie Fiedler,Gerd Meyer zu Hörste,Anne-K Mausberg,Clemens Kill,Michael Forsting,Ulrich Sure,Ulf Dittmer,Oliver Witzke,Thorsten Brenner,Christoph Kleinschnitz,Mark Stettner +21 more
TL;DR: A growing number of reports suggest that infection with SARS-CoV-2 often leads to neurological involvement; however, data on the incidence and severity are limited to mainly case reports as discussed by the authors.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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