Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Covid-19: End of the beginning?
TL;DR: The limited case cluster of atypical pneumonia detected in central China in December 2019, now known as Coronavirus Disease 2019 (Covid-19), converted into a million confirmed cases worldwide in only 10 weeks, indicating the world is under formidable strain with respect to public health, economy and personal life.
Journal ArticleDOI
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19.
Walid Hamouche,Malik Bisserier,Agnieszka Brojakowska,Abrisham Eskandari,Kenneth Fish,David A. Goukassian,Lahouaria Hadri +6 more
TL;DR: The epidemiological data from various COVID-19 patient cohorts around the world and the USA as well the associated risk factors are discussed, the pathophysiology of SARS-CoV-2 infection and the underlying molecular mechanisms for the respiratory and cardiovascular manifestations are summarized and the potential treatments and vaccines are highlighted.
Journal ArticleDOI
Mechanisms of stroke in coronavirus disease 2019
TL;DR: Evidence suggests that the severity of COVID-19 infection is directly related to the presence of HTN, DM, obesity, and elderly status that also increase the risk of developing stroke mainly from small vessel occlusion, LVD, and cardioembolism.
Journal ArticleDOI
Thrombosis at hospital presentation in patients with and without coronavirus disease 2019.
Shari B. Brosnahan,Nathaniel R. Smilowitz,Nancy Amoroso,Michael E. Barfield,Jeffery S. Berger,Ronald Goldenberg,Koto Ishida,Nina Talmor,Jose Torres,Shadi Yaghi,Eugene Yuriditsky,Thomas S. Maldonado +11 more
TL;DR: Outpatients with COVID-19 who developed thrombosis requiring hospitalization have an increased mortality over non-CO VID-19 outpatients who developThrombotic disease in these patients, given the significantly higher inflammatory markers.
Journal ArticleDOI
Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
Charles de Marcellus,L. Dupic,Charles-Joris Roux,Imane El Aouane El Ghomari,Perrine Parize,Romain Luscan,Florence Moulin,Manoelle Kossorotoff +7 more
TL;DR: In this paper, a case of an adolescent who presented with febrile meningism and stupor was diagnosed with Lemierre syndrome (LS), with Fusobacterium necrophorum infection (sphenoid sinusitis and meningitis) and intracranial vasculitis.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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