Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
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Naturally Occurring Animal Coronaviruses as Models for Studying Highly Pathogenic Human Coronaviral Disease.
TL;DR: The emergence of highly pathogenic or infectious CoVs in humans over the past 20 years, including severe acute respiratory syndrome CoV (SARS-CoV), Middle East respiratory syndrome Coronavirus (MERS)-CoV, and most recently SARS CoV-2, underscores the significant threat that CoV spillovers pose to humans as mentioned in this paper.
Journal ArticleDOI
The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
Qin Ning,Di Wu,Xiaojing Wang,Dong Xi,Tao Chen,Guang-Hua Chen,Hong Wang,Huiling Lu,Ming Wang,Lin Zhu,Junjian Hu,Tingting Liu,Ke Ma,Meifang Han,Xiaoping Luo +14 more
TL;DR: In this article , the authors provide an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focus on the pathogenesis and potential therapeutic targets for the management of CoV-19.
Journal ArticleDOI
Surveillance Study of Acute Neurological Manifestations among 439 Egyptian Patients with COVID-19 in Assiut and Aswan University Hospitals.
Eman M. Khedr,Noha Abo-Elfetoh,Enas A.E. Deaf,Hebatallah M. Hassan,Mariam T. Amin,Radwa K. Soliman,Alaa A. Attia,Amro A. Zarzour,Mohamed E. Zain,Aliae Mohamed-Hussein,Maiada K. Hashem,Sahar M Hassany,Ahmed Aly,Ahmed Shoyb,Mostafa Saber +14 more
TL;DR: In COVID-19, both the CNS and PNS are affected and Stroke was the most common complication for CNS and anosmia and/or ageusia were common for PNS diseases.
Journal ArticleDOI
Clinical features of thrombosis and bleeding in COVID-19
Mari Thomas,Marie Scully +1 more
TL;DR: All patients should receive thromboprophylaxis when admitted with COVID-19 infection, but the dose and length of treatment still remain debated, and adjustments may be required depending on other factors relevant to the patient admission.
Journal ArticleDOI
Neurological Symptoms, Comorbidities, and Complications of COVID-19: A Literature Review and Meta-Analysis of Observational Studies
Kimia Vakili,Mobina Fathi,Mohammadreza Hajiesmaeili,Melika Salari,Diksha Saluja,Abbas Tafakhori,Fatemeh Sayehmiri,Mostafa Rezaei-Tavirani +7 more
TL;DR: The most prevalent neurological manifestations of COVID-19 include fatigue, gustatory dysfunction, anorexia, olfactory dysfunction, headache, dizziness, and nausea as discussed by the authors.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
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Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
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COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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