Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
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AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
Waldemar A. Turski,Artur Wnorowski,Gabrielle N. Turski,Gabrielle N. Turski,Christopher A. Turski,Christopher A. Turski,Lechoslaw Turski +6 more
TL;DR: It is hypothesize that elimination of factors known to up-regulate AhRs, or implementation of measures known to down- Regulate AhR, should decrease severity of infection.
Journal ArticleDOI
Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis.
TL;DR: Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality and further study is needed to elucidate the pathophysiology and prognosis of stroke in CO VID-19 to achieve most effective care.
Journal ArticleDOI
von Willebrand Factor Multimer Formation Contributes to Immunothrombosis in Coronavirus Disease 2019.
Adrian Doevelaar,Martin Bachmann,Bodo Hölzer,Felix S. Seibert,Benjamin Rohn,Frederic Bauer,Oliver Witzke,Ulf Dittmer,Michael Bachmann,Serap Yilmaz,Rita Dittmer,Sonja Schneppenheim,Nina Babel,Ulrich Budde,Timm H. Westhoff +14 more
TL;DR: In this paper, the ADAMTS13/von Willebrand factor antigen ratio was significantly lower in COVID-19 than in the control group (24.4 ± 20.5 vs 82.0 ± 30.7; p < 0.18).
Journal ArticleDOI
Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19).
Niloufar Yazdanpanah,Niloufar Yazdanpanah,Amene Saghazadeh,Amene Saghazadeh,Nima Rezaei,Nima Rezaei +5 more
TL;DR: The observation of anosmia would direct us to find the pathogenesis of COVID-19 in the central nervous system, and this is consistent with numerous neurological manifestations related to CO VID-19.
Posted ContentDOI
Early postmortem brain MRI findings in COVID-19 non-survivors
Tim Coolen,Valentina Lolli,Niloufar Sadeghi,Antonin Rovai,Nicola Trotta,Fabio Silvio Taccone,Jacques Creteur,Sophie Henrard,Jean-Christophe Goffard,Olivier De Witte,Gilles Naeije,Serge Goldman,Xavier De Tiège +12 more
TL;DR: Postmortem brain MRI demonstrates hemorrhagic and PRES-related brain lesions in non-survivors of COVID-19 that might be triggered by the virus-induced endothelial disturbances and the absence of brainstem MRI abnormalities does not support a brain-related contribution to respiratory distress in CO VID-19.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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