Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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COVID-19 and thrombosis: From bench to bedside.
Mohammed K. Ali,Sarah A Spinler +1 more
TL;DR: This review will analyze the current available knowledge of the association between COVID-19 and thrombosis, and highlight mechanisms at both molecular and cellular levels that may explain this association.
Journal ArticleDOI
Synthetic data in machine learning for medicine and healthcare.
Richard J. Chen,Ming Y. Lu,Ming Y. Lu,Ming Y. Lu,Tiffany Y. Chen,Tiffany Y. Chen,Drew F. K. Williamson,Drew F. K. Williamson,Faisal Mahmood,Faisal Mahmood,Faisal Mahmood +10 more
TL;DR: The proliferation of synthetic data in artificial intelligence for medicine and healthcare raises concerns about the vulnerabilities of the software and the challenges of current policy as mentioned in this paper, and the challenge of current policies.
Journal ArticleDOI
Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection.
Torben Kimhofer,Samantha Lodge,Luke Whiley,Luke Whiley,Nicola Gray,Ruey Leng Loo,Nathan G. Lawler,Philipp Nitschke,Sze-How Bong,David Morrison,Sofina Begum,Toby Richards,Bu B. Yeap,Chris Smith,Kenneth G. C. Smith,Elaine Holmes,Elaine Holmes,Jeremy K. Nicholson,Jeremy K. Nicholson,Jeremy K. Nicholson +19 more
TL;DR: The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidemia, diabetes, and coronary heart disease risk that is consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
Journal ArticleDOI
Neurological manifestations associated with SARS-CoV-2 and other coronaviruses: A narrative review for clinicians.
TL;DR: The aim of this review was to summarize the current data about neurological manifestations and diseases linked to human coronavirus and neurology search terms and adding relevant references in the articles.
Journal ArticleDOI
MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy.
TL;DR: It is paramount to only use well-characterized, safe MSCs even in the most urgent and experimental treatments, and to integrate both innate and adaptive immune compatibility testing into the current guidelines for cell, tissue, and organ transplantation is critical for safe and effective therapies.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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