Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19.
Aristides M. Tsatsakis,Aristides M. Tsatsakis,Daniela Calina,Luca Falzone,Dimitrios Petrakis,Radu Mitrut,Vasileios Siokas,Manuela Pennisi,Giuseppe Lanza,Massimo Libra,Sotirios G. Doukas,Sotirios G. Doukas,Panagiotis G Doukas,Leena Kavali,Amar Bukhari,Chiranjeevi Gadiparthi,Dimitra P. Vageli,Diamantis P. Kofteridis,Demetrios A. Spandidos,Monica Maria Bastos Paoliello,Michael Aschner,Anca Oana Docea +21 more
TL;DR: The present review summarizes the current, though admittedly fluid knowledge on the pathophysiology and symptoms of COVID-19 infection and contributes to a more complete understanding of the disease, and may drive the direction of new research.
Journal ArticleDOI
Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19.
Ranju T. Dhawan,Ranju T. Dhawan,Deepa Gopalan,Luke Howard,Angelito Vicente,Mirae Park,Kavina Manalan,Kavina Manalan,Ingrid Wallner,Peter Marsden,Surendra Dave,Howard Branley,Georgina Russell,Nishanth Dharmarajah,Onn Min Kon,Onn Min Kon +15 more
TL;DR: A proactive follow-up strategy to evaluate residual clot burden, small vessel injury, and potential haemodynamic sequelae of COVID-19 is proposed, with the potential to inform therapeutic strategies.
Journal ArticleDOI
Neurological manifestations and implications of COVID-19 pandemic
Georgios Tsivgoulis,Lina Palaiodimou,Aristeidis H. Katsanos,Valeria Caso,Martin Köhrmann,Carlos A. Molina,Charlotte Cordonnier,Urs Fischer,Peter J. Kelly,Vivek Sharma,Amanda C. Chan,Ramin Zand,Amrou Sarraj,Peter D. Schellinger,Konstantinos Voumvourakis,Nikolaos Grigoriadis,Andrei V. Alexandrov,Sotirios Tsiodras +17 more
TL;DR: Regardless of any direct or indirect neurological manifestations, the COVID-19 pandemic has a huge impact on the management of neurological patients, whether infected or not, and the majority of stroke services worldwide have been negatively influenced in terms of care delivery and fear to access healthcare services.
Journal ArticleDOI
Global impact of COVID-19 on stroke care.
Raul G Nogueira,Mohamad Abdalkader,Muhammed M. Qureshi,Michael Frankel,Ossama Mansour,Hiroshi Yamagami,Zhongming Qiu,Mehdi Farhoudi,James E. Siegler,Shadi Yaghi,Eytan Raz,Nobuyuki Sakai,Nobuyuki Ohara,Michel Piotin,Laura Mechtouff,Omer Eker,Vanessa Chalumeau,Timothy Kleinig,Raoul Pop,Jianmin Liu,Hugh Stephen Winters,Xianjin Shang,Alejandro Rodriguez Vasquez,Jordi Blasco,Juan F. Arenillas,Mario Martínez-Galdámez,Alex Brehm,Marios-Nikos Psychogios,Pedro Lylyk,Diogo C Haussen,Alhamza R Al-Bayati,Mahmoud H Mohammaden,Luisa Fonseca,M. Luis Silva,Francisco Mont’Alverne,Leonardo Renieri,Salvatore Mangiafico,Urs Fischer,Jan Gralla,Donald Frei,Chandril Chugh,Brijesh P Mehta,Simon Nagel,Markus A Möhlenbruch,Santiago Ortega-Gutierrez,Mudassir Farooqui,Ameer E Hassan,Allan Taylor,Bertrand Lapergue,Arturo Consoli,Bruce C.V. Campbell,Malveeka Sharma,Melanie Walker,Noel van Horn,Jens Fiehler,Huy Thang Nguyen,Quoc Trung Nguyen,Daisuke Watanabe,Hao Zhang,Huynh Vu Le,Viet Quy Nguyen,Ruchir Shah,Thomas Devlin,Priyank Khandelwal,Italo Linfante,Wazim Izzath,Pablo M. Lavados,Verónica V. Olavarría,Gisele Sampaio Silva,Anna Verena de Carvalho Sousa,Jawad F. Kirmani,Martin Bendszus,Tatsuo Amano,Ryoo Yamamoto,Ryosuke Doijiri,Naoki Tokuda,Takehiro Yamada,Tadashi Terasaki,Yukako Yazawa,Jane G. Morris,Emma Griffin,John Thornton,Pascale Lavoie,Charles C. Matouk,Michael D. Hill,Andrew M. Demchuk,Monika Killer-Oberpfalzer,Fadi Nahab,Dorothea Altschul,Anna Ramos-Pachón,Natalia Pérez de la Ossa,Raghid Kikano,William Boisseau,Gregory Walker,Steve M. Cordina,Ajit S. Puri,Anna Luisa Kühn,Dheeraj Gandhi,Pankajavalli Ramakrishnan,Roberta Novakovic-White,Alex Bou Chebl,Odysseas Kargiotis,Alexandra L Czap,Alicia Zha,Hesham Masoud,Carlos Ynigo Lopez,David Ozretić,Fawaz Al-Mufti,Wenjie Zie,Zhenhui Duan,Zhengzhou Yuan,Wenguo Huang,Yonggang Hao,Jun Luo,Vladimir Kalousek,Romain Bourcier,Romain Guile,Steven W. Hetts,Hosam Al-Jehani,Adel Alhazzani,Elyar Sadeghi-Hokmabadi,Mohamed Teleb,Jeremy Payne,Jin Soo Lee,Ji Man Hong,Sung Il Sohn,Yang-Ha Hwang,Dong Hoon Shin,Hong Gee Roh,Randy Edgell,Rakesh Khatri,Ainsley Smith,Amer M. Malik,David S Liebeskind,Nabeel Herial,Pascal Jabbour,Pedro S.C. Magalhães,Atilla Özcan Özdemir,Özlem Aykaç,Takeshi Uwatoko,Tomohisa Dembo,Hisao Shimizu,Yuri Sugiura,Fumio Miyashita,Hiroki Fukuda,Kosuke Miyake,Junsuke Shimbo,Yusuke Sugimura,André Beer-Furlan,Krishna C Joshi,Luciana Catanese,Daniel Giansante Abud,Octavio Giansante Neto,Masoud Mehrpour,Amal Al Hashmi,Mahar Saqqur,Abdulrahman Mostafa,Johanna T Fifi,Syed T. Hussain,Seby John,Rishi Gupta,Rotem Sivan-Hoffmann,Anna Reznik,Achmad Fidaus Sani,Serdar Geyik,Eşref Akıl,Anchalee Churojana,Abdoreza Ghoreishi,Mohammad Saadatnia,Ehsan Sharifipour,Alice Ma,Ken Faulder,Teddy Y. Wu,Lester Y. Leung,Adel M. Malek,Barbara Voetsch,Ajay K. Wakhloo,Rodrigo Rivera,Danny Moises Barrientos Iman,Aleksandra Pikula,Vasileios-Arsenios Lioutas,Götz Thomalla,Lee Birnbaum,Paolo Machi,Gianmarco Bernava,Mollie McDermott,Dawn Kleindorfer,Ken Wong,Mary S. Patterson,Jose Antonio Fiorot,Vikram Huded,William J. Mack,Matthew S. Tenser,Clifford J. Eskey,Sumeet Multani,Michael Kelly,Vallabh Janardhan,Oriana Cornett,Varsha Singh,Yuichi Murayama,Maxim Mokin,Pengfei Yang,Xiaoxi Zhang,Congguo Yin,Hongxing Han,Ya Peng,Wenhuo Chen,Roberto Crosa,Michel Frudit,Jeyaraj D Pandian,Anirudh Kulkarni,Yoshiki Yagita,Yohei Takenobu,Yuji Matsumaru,Satoshi Yamada,Ryuhei Kono,Takuya Kanamaru,Hidekazu Yamazaki,Manabu Sakaguchi,Kenichi Todo,Nobuaki Yamamoto,Kazutaka Sonoda,Tomoko Yoshida,Hiroyuki Hashimoto,Ichiro Nakahara,Elena A. Cora,David Volders,Célina Ducroux,Ashkan Shoamanesh,Johanna M. Ospel,Artem Kaliaev,Saima Ahmed,Umair Rashid,Leticia C Rebello,Vitor Mendes Pereira,Robert Fahed,Michael Chen,Sunil A Sheth,Lina Palaiodimou,Georgios Tsivgoulis,Ronil V. Chandra,Feliks Koyfman,Thomas W. Leung,Houman Khosravani,Sushrut Dharmadhikari,Giovanni Frisullo,Paolo Calabresi,Alexander Tsiskaridze,Nino Lobjanidze,Mikayel Grigoryan,Anna Członkowska,Diana Aguiar de Sousa,Jelle Demeestere,Conrad W Liang,Navdeep Sangha,Helmi L. Lutsep,Óscar Ayo-Martín,Antonio Cruz-Culebras,Anh D. Tran,Chang Y. Young,Charlotte Cordonnier,François Caparros,María Alonso de Leciñana,Blanca Fuentes,Dileep R. Yavagal,Tudor G Jovin,Laurent Spelle,Jacques Moret,Pooja Khatri,Osama O. Zaidat,Jean Raymond,Sheila Cristina Ouriques Martins,Thanh N. Nguyen +272 more
TL;DR: In this paper, the authors measured the global impact of the COVID-19 pandemic on the volumes of the volumes for medical care in the United Kingdom and the United States.
Journal ArticleDOI
Cerebrovascular events and outcomes in hospitalized patients with COVID-19: The SVIN COVID-19 Multinational Registry.
James E. Siegler,James E. Siegler,Pere Cardona,Juan F. Arenillas,Juan F. Arenillas,Blanca Talavera,A. Guillen,Alba Chavarría-Miranda,Mercedes de Lera,Priyank Khandelwal,Ivo Bach,Pratit Patel,Amit Singla,Manuel Requena,Marc Ribo,Dinesh V Jillella,Srikant Rangaraju,Raul G Nogueira,Raul G Nogueira,Diogo C Haussen,Diogo C Haussen,Alejandro Vazquez,Xabier Urra,Ángel Chamorro,Luis San Roman,Jesse M. Thon,Jesse M. Thon,Ryna Then,Ryna Then,Emma Sanborn,Emma Sanborn,Natalia Pérez de la Ossa,Mónica Millán,Isaac N Ruiz,Ossama Mansour,Mohammed Megahed,Cristina Tiu,Elena Oana Terecoasa,Razvan Alexandru Radu,Thanh N. Nguyen,Thanh N. Nguyen,Gioacchino Curiale,Artem Kaliaev,Alexandra L Czap,Jacob Sebaugh,Alicia M Zha,David S Liebeskind,Santiago Ortega-Gutierrez,Mudassir Farooqui,Ameer E Hassan,Laurie Preston,Mary S. Patterson,Saif Bushnaq,Osama O. Zaidat,Tudor G Jovin,Tudor G Jovin +55 more
TL;DR: COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke, and aggressive monitoring and early intervention should be pursued to mitigate poor outcomes.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
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Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
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Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
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COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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