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Open AccessJournal ArticleDOI

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.

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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.
Abstract
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....

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Top 100 Most Cited Neurologic and Neurosurgical Articles on COVID-19: A Bibliometric Analysis

- 01 Jan 2022 - 
TL;DR: In this paper , the authors identified and characterized the 100 most cited COVID-19-related articles in neurology and neurosurgery using a title-specific search of the Scopus database.
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Cervical spinal cord infarction associated with coronavirus infectious disease (COVID)-19.

TL;DR: In this paper, a case of a previously healthy young man with severe COVID-19 who subsequently developed an acute flaccid paralysis was described, and the lesion in his cervical spinal cord concerning for spinal infarction or transverse myelitis.
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A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases.

TL;DR: It is argued that cytokine balance may be restored by recovering an IL-6 trans-signaling neutralizing buffer system through the mediation of recombinant soluble glycoprotein 130 and recombinant ADAM17/TACE prodomain inhibitor and introduced as a novel approach to treat patients with severe COVID-19.
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Clinical Experience, Pathophysiology, and Considerations in the Prophylaxis and Treatment of Hypercoagulopathy of COVID-19: A Review Study

TL;DR: In this article, the authors reviewed the incidence and possible mechanisms of thrombotic complications, and presented a summary of the considerations for the prophylaxis and treatment of such complications in the adult population.
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COVID-19 associated nervous system manifestations

TL;DR: In this article , a review of observed neurological manifestations associated with COVID-19 is provided, which indicate that SARS-CoV-2 can be considered as an opportunistic pathogen of the brain.
References
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Journal ArticleDOI

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.

TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
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Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).

TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
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Erythropoietin as candidate for supportive treatment of severe COVID-19.

TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
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Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?

TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
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COVID-19-associated pulmonary and cerebral thromboembolic disease

TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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