Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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4,4'-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor.
TL;DR: By examining the use of 4,4′-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen’s disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes.
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Tocilizumab as a Therapeutic Agent for Critically Ill Patients Infected with SARS-CoV-2
Russell M. Petrak,Nathan C. Skorodin,Nicholas W. Van Hise,Robert M. Fliegelman,Jonathan Pinsky,Vishal Didwania,Michael Anderson,Melina Diaz,Kairav Shah,Vishnu Chundi,David W. Hines,Brian P. Harting,Kamo Sidwha,Brian Yu,Paul Brune,Anjum Owaisi,David Beezhold,Joseph Kent,Dana Vais,Alice Han,Neethi Gowda,Nishi Sahgal,Jan Silverman,Jonathan Stake,Jenie Nepomuceno,Renuka Heddurshetti +25 more
TL;DR: Tocilizumab therapy was effective at decreasing mortality and should be instituted early in the management of critically ill COVID-19 patients, according to the results of a multi-center study.
Journal ArticleDOI
Transcranial Doppler Ultrasound Evidence of Active Cerebral Embolization in COVID-19.
Ayush Batra,Jeffrey R. Clark,Katie LaHaye,Nathan A. Shlobin,Steven C. Hoffman,Zachary S. Orban,Katharine Colton,Jane Dematte,Farzaneh A. Sorond,Igor J. Koralnik,Eric M. Liotta +10 more
TL;DR: TCD ultrasonography provides a non-invasive method for evaluating cerebral microemboli in patients with COVID-19 and may be useful in assessing response to treatment in cases with suspected or confirmed disorders of hypercoagulability.
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Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells
Xammy Nguyenla,Eddie Wehri,Erik Van Dis,Scott B. Biering,Lívia H. Yamashiro,Julien R. Stroumza,Claire Dugast-Darzacq,Thomas G.W. Graham,Sarah A. Stanley,Julia Schaletzky +9 more
TL;DR: It is suggested that the FDA-approved Hepatitis C therapeutics Epclusa and Zepatier should be fast-tracked for clinical evaluation in combination with remdesivir to improve treatment of acute SARS-CoV-2 infections.
Journal ArticleDOI
The Association of Low Molecular Weight Heparin Use and In-hospital Mortality Among Patients Hospitalized with COVID-19.
Lan Shen,Lin Qiu,Dong Liu,Li Wang,Hengye Huang,Heng Ge,Ying Xiao,Yi Liu,Jingjin Jin,Xiulan Liu,Dao Wen Wang,Eric D. Peterson,Ben He,Ning Zhou +13 more
TL;DR: In this article, the association between low molecular weight heparin (LMWH) use and mortality in hospitalized COVID-19 patients was investigated and the primary outcome was adjusted in-hospital mortality in the LMWH group compared with the non-LMWH group using the propensity score.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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