Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Peripheral Nervous System Manifestations Associated with COVID-19.
Sasan Andalib,José Biller,Mario Di Napoli,Narges Moghimi,Louise D. McCullough,Clio Rubinos,Christa O'Hana S. Nobleza,M. Reza Azarpazhooh,Luciana Catanese,Isabel Elicer,Mostafa Jafari,Fabrizio Liberati,Claudia Camejo,Michel T. Torbey,Afshin A. Divani +14 more
TL;DR: There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms, including headache, impaired consciousness, delirium, loss of smell and taste.
Journal ArticleDOI
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19
TL;DR: The combination of acute lung injury with RAS-KKS unbalance is herein called COVID-19 Associated Lung Injury (CALI), a conservative two-hit model of systemic inflammation due to the lung injury that allows new intervention windows and is more consistent with the current knowledge.
Journal ArticleDOI
Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses.
Eleni Gavriilaki,Panagiota Anyfanti,Maria Gavriilaki,Antonios Lazaridis,Stella Douma,Eugenia Gkaliagkousi +5 more
TL;DR: Endothelial dysfunction is the common denominator of multiple clinical aspects of severe COVID-19 infection that have been problematic for treating physicians, and better understanding of the pathophysiology could significantly affect management of patients.
Journal ArticleDOI
Paracentral acute middle maculopathy and acute macular neuroretinopathy following SARS-CoV-2 infection.
Jonathan Virgo,Moin Mohamed +1 more
TL;DR: COVID-19 has been reported in association with acute limb ischaemia, stroke and the so called “paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection” and PAMM and AMN have similar underlying pathophysiology.
Journal ArticleDOI
COVID-19: Complement, Coagulation, and Collateral Damage.
TL;DR: A summary of CO VID-19 is provided and complement’s role in COVID-19 acute respiratory distress syndrome and coagulopathy is reviewed, suggesting that the complement system plays a key role in this inflammatory reaction.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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