Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
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Thrombosis in COVID-19.
TL;DR: Several mechanisms of hypercoagulability in sepsis that may be upregulated in COVID‐19, including immune‐mediated thrombotic mechanisms, complement activation, macrophage activation syndrome, antiphospholipid antibody syndrome, hyperferritinemia, and renin‐angiotensin system dysregulation are reviewed.
Journal ArticleDOI
Interplay between inflammation and thrombosis in cardiovascular pathology.
TL;DR: In this paper, the synergy between inflammation and thrombosis is discussed, and the huge potential of anti-inflammatory strategies to target cardiovascular pathologies is highlighted, with the aim of covering therapeutic gaps in cardiovascular diseases.
Journal ArticleDOI
Neurological Involvement in COVID-19 and Potential Mechanisms: A Review.
Ghazal Aghagoli,Benjamin Gallo Marin,Nicole J Katchur,Franz Chaves-Sell,Wael F. Asaad,Sarah Murphy +5 more
TL;DR: A range of clinical observations and initial case series describing potential neurologic manifestations of COVID-19 are synthesized and place these observations in the context of coronavirus neuro-pathophysiology as it may relate to SARS-CoV-2 infection.
Journal ArticleDOI
Frequent neurocognitive deficits after recovery from mild COVID-19
Marcel S Woo,Jakob Heinrich Malsy,Jana Pöttgen,Susan Seddiq Zai,Friederike Ufer,Alexandros Hadjilaou,Stefan Schmiedel,Marylyn M. Addo,Christian Gerloff,Christoph Heesen,Julian Schulze zur Wiesch,Manuel A. Friese +11 more
TL;DR: It is demonstrated that sustained sub-clinical cognitive impairments might be a common complication after recovery from COVID-19 in young adults, regardless of clinical course that were unmasked by the diagnostic approach.
Journal ArticleDOI
Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium.
Sherry H.-Y. Chou,Ettore Beghi,Raimund Helbok,Elena Moro,Joshua N. Sampson,Valeria Altamirano,Shraddha Mainali,Claudio L. Bassetti,Claudio L. Bassetti,Jose I. Suarez,Molly McNett +10 more
TL;DR: In this paper, the authors found that the presence of clinically captured neurological signs and/or syndromes was associated with increased risk of in-hospital death (adjusted odds ratio [aOR], 5.99; 95% CI, 4.33-8.28) after adjusting for study site, age, sex, race, and ethnicity.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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