Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Journal ArticleDOI
Pathogenesis and management of myocardial injury in coronavirus disease 2019.
TL;DR: The current review summarizes the epidemiological characteristics, potential mechanisms, clinical manifestations, and recent progress in the management of COVID‐19 cardiovascular complications.
Posted ContentDOI
IgM autoantibodies recognizing ACE2 are associated with severe COVID-19
Livia Casciola-Rosen,David R. Thiemann,Felipe Andrade,Maria Isabel Trejo Zambrano,Jody E. Hooper,Elissa K. Leonard,Jamie B. Spangler,Jamie B. Spangler,Andrea L. Cox,Carolyn E. Machamer,Lauren M. Sauer,Oliver Laeyendecker,Oliver Laeyendecker,Brian T. Garibaldi,Stuart C. Ray,Christopher A. Mecoli,Lisa Christopher-Stine,Laura Gutierrez-Alamillo,Qingyuan Yang,David Hines,William Clarke,Richard E. Rothman,Andrew Pekosz,Katherine J. Fenstermacher,Zitong Wang,Scott L. Zeger,Antony Rosen +26 more
TL;DR: It is proposed that vascular endothelial ACE2 expression focuses the pathogenic effects of these autoantibodies on blood vessels, and contributes to the angiocentric pathology observed in some severe COVID-19 patients.
Journal ArticleDOI
Thromboembolic Risk in Hospitalized and Nonhospitalized COVID-19 Patients: A Self-Controlled Case Series Analysis of a Nationwide Cohort.
Frederick K. Ho,Kenneth K.C. Man,Kenneth K.C. Man,Mark Toshner,Colin Church,Carlos Celis-Morales,Ian C.K. Wong,Ian C.K. Wong,Colin Berry,Naveed Sattar,Jill P. Pell +10 more
TL;DR: In this article, a self-controlled case-series study was conducted to assess the associations between coronavirus disease 2019 (COVID-19) infection and thromboembolism including myocardial infarction (MI), ischemic stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE).
Journal ArticleDOI
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19
Christos Pantelis,Mahesh Jayaram,Anthony J. Hannan,Robb Wesselingh,Jess Nithianantharajah,Cassandra Wannan,Warda Syeda,Kh Christopher Choy,Kh Christopher Choy,Daniela Zantomio,Arthur Christopoulos,Dennis Velakoulis,Dennis Velakoulis,Terence J. O'Brien,Terence J. O'Brien +14 more
TL;DR: The impact of SARS-CoV-2 (the coronavirus causing CO VID-19) on the central nervous system is highlighted as there is an urgent need to understand the longitudinal impacts of COVID-19 on brain function, behaviour and cognition.
Journal ArticleDOI
Etiologic Subtypes of Ischemic Stroke in SARS-CoV-2 Patients in a Cohort of New York City Hospitals
Ambooj Tiwari,Ketevan Berekashvili,Volodomyr Vulkanov,Shashank Agarwal,Amit Khaneja,David Turkel-Parella,Jeremy Liff,Jeffrey Farkas,Thambirajah Nandakumar,Ting Zhou,Jennnifer Frontera,David Kahn,Sun Kim,Kelly A Humbert,Matthew Sanger,Shadi Yaghi,Aaron Lord,Karthikeyan Arcot,Adam A Dmytriw +18 more
TL;DR: The ischemic stroke subtypes related to coronavirus disease 2019 (COVID-19) in a cohort of New York City hospitals and explore their etiopathogenesis can present as small vessel occlusions, branch emboli or large vessel Occlusions.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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