Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations.
Caroline Diorio,Kevin O McNerney,Michele P. Lambert,Michele Paessler,Elizabeth M. Anderson,Sarah E. Henrickson,Julie Chase,Emily J. Liebling,Chakkapong Burudpakdee,Jessica H. Lee,Fran Balamuth,Allison M. Blatz,Kathleen Chiotos,Julie C. Fitzgerald,Therese M. Giglia,Kandace Gollomp,Audrey R. Odom John,Cristina Jasen,Tomas Leng,Whitney Petrosa,Laura A. Vella,Char Witmer,Kathleen E. Sullivan,Benjamin L. Laskin,Scott E. Hensley,Hamid Bassiri,Edward M. Behrens,David T. Teachey +27 more
TL;DR: A high proportion of tested children with SARS-CoV-2 infection had evidence of complement activation and met clinical and diagnostic criteria for TMA, and if there are any short- or long-term clinical consequences of complementactivation and endothelial damage in children with COVID-19 or MIS-C is needed.
Journal ArticleDOI
Pathogenesis, clinical manifestations and complications of coronavirus disease 2019 (COVID-19).
TL;DR: Respiratory system and the lungs are the most commonly involved sites of COVID-19 infection and cardiovascular, liver, kidneys, gastrointestinal and central nervous systems are involved with different frequencies and degrees of severity.
Journal ArticleDOI
Neurological involvement of coronavirus disease 2019: a systematic review.
Malik Ghannam,Qasem Alshaer,Mustafa Al-Chalabi,Lara Zakarna,Jetter Robertson,Georgios Manousakis +5 more
TL;DR: A systematic literature search using multiple combinations of keywords from PubMed and Ovid Medline databases was able to identify 82 cases of COVID-19 with neurological complications, which are not rare but should be cautious not to overlook other neurological diagnoses that can mimic CO VID-19 during the pandemic.
Journal ArticleDOI
The Impact of SARS-CoV-2 on Stroke Epidemiology and Care: A Meta-analysis
Aristeidis H. Katsanos,Aristeidis H. Katsanos,Lina Palaiodimou,Ramin Zand,Shadi Yaghi,Hooman Kamel,Babak B. Navi,Guillaume Turc,Michele Romoli,Vivek Sharma,Dimitris Mavridis,Dimitris Mavridis,Shima Shahjouei,Luciana Catanese,Ashkan Shoamanesh,Konstantinos Vadikolias,Konstantinos Tsioufis,Pagona Lagiou,Pagona Lagiou,Andrei V Alexandrov,Sotirios Tsiodras,Georgios Tsivgoulis,Georgios Tsivgoulis +22 more
TL;DR: A systematic review and meta‐analysis of emerging data indicate an increased risk of cerebrovascular events with severe acute respiratory syndrome coronavirus 2 and the potential impact of coronav virus disease (COVID‐19) on the management and outcomes of acute stroke.
Journal ArticleDOI
Clinical Outcomes in Patients With Heart Failure Hospitalized With COVID-19.
Ankeet S. Bhatt,Karola S. Jering,Muthiah Vaduganathan,Brian Claggett,Jonathan W. Cunningham,Ning Rosenthal,James Signorovitch,Jens Jakob Thune,Orly Vardeny,Scott D. Solomon +9 more
TL;DR: In this paper, the authors evaluated in-hospital outcomes among patients with a history of heart failure (HF) hospitalized with coronavirus disease-2019 (COVID-19) who were subsequently hospitalized between April and September 2020.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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