Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young.
Thomas J Oxley,J Mocco,Shahram Majidi,Christopher P. Kellner,Hazem Shoirah,I. Paul Singh,Reade De Leacy,Tomoyoshi Shigematsu,Travis R. Ladner,Kurt A. Yaeger,Maryna Skliut,Jesse Weinberger,Neha S. Dangayach,Joshua B. Bederson,Stanley Tuhrim,Johanna T Fifi +15 more
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TLDR
Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period with signs of stroke and infection.Abstract:
Stroke in Young Patients with Covid-19 Five patients younger than 50 years of age with large-vessel stroke and Covid-19 infection presented to a health system in New York City over a 2-week period....read more
Citations
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Coagulopathy associated with COVID-19 – Perspectives &Preventive strategies using a biological response modifier Glucan
Nobunao Ikewaki,Nobunao Ikewaki,K.S.J. Rao,Armando Durant Archibold,Masaru Iwasaki,Rajappa Senthilkumar,Senthilkumar Preethy,Shojiro Katoh,Samuel J. K. Abraham +8 more
TL;DR: The perspectives on the effect of regular supplementation with the biological response modifier beta glucan based on its relevance to immune modulation are presented, of paramount importance in decreasing the development of severe COVID-19 and reducing mortality against the background of coagulopathy, especially in vulnerable populations.
Journal ArticleDOI
SARS-CoV-2 Is Not Detected in the Cerebrospinal Fluid of Encephalopathic COVID-19 Patients
Dimitris G. Placantonakis,Maria E Aguero-Rosenfeld,Abdallah Flaifel,John Colavito,Kenneth Inglima,David Zagzag,Matija Snuderl,Eddie Louie,Jennifer A. Frontera,Ariane Lewis +9 more
TL;DR: It is found that the mRNAs encoding the ACE2 receptor and the TMPRSS2 transmembrane serine protease, both of which are required for viral entry into host cells, are minimally expressed in the major cell types of the brain.
Journal ArticleDOI
Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia.
Nikiforos Galanis,Chara Stavraka,Filon Agathangelidis,Evangelos Petsatodis,Christos Giankoulof,Panagiotis Givissis +5 more
TL;DR: A case of severe coagulopathy manifesting with right upper limb arterial and deep vein thrombosis in an 80-year-old male patient with severe COVID-19 associated pneumonia, which led to his death from respiratory failure.
Journal ArticleDOI
Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review
Graziella Orrù,Ciro Conversano,Eleonora Malloggi,Francesca Francesconi,Rebecca Ciacchini,Angelo Gemignani +5 more
TL;DR: A systematic review of studies investigating neurologic manifestations of SARS-CoV-2 in patients over 18 found the most frequent disorders affecting central nervous system (CNS) seem to be the following: olfactory and taste disorders, ischemic/hemorrhagic stroke, meningoencephalitis and encephalopathy, including acute necrotizing encephalitis, a rare type of encephalopathic disease.
Journal ArticleDOI
Neurological issues during COVID-19: An overview.
Avindra Nath,Bryan Smith +1 more
TL;DR: Novel clinical trial designs need to be considered so that multiple agents can be studied in patients infected with SARS-CoV-2 and disease pathophysiology and standardized batteries and biological markers for patient assessment need to been developed.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Large artery ischaemic stroke in severe acute respiratory syndrome (SARS).
T. Umapathi,Ai Ching Kor,Narayanaswamy Venketasubramanian,C. C. Tchoyoson Lim,Boon Chuan Pang,Tseng Tsai Yeo,Cheng Chuan Lee,Poh Lian Lim,Poh Lian Lim,Kuperan Ponnudurai,Khoon Leong Chuah,Puay Hoon Tan,Dessmon Y.H. Tai,Sze Peng Brenda Ang +13 more
TL;DR: It is believed that increased vigilance against stroke and other thrombotic complications among critically-ill SARS patients in future outbreaks is needed, especially if treatment such as intravenous immunoglobulin, that increases pro-thrombosis tendency, is contemplated.
Journal ArticleDOI
Erythropoietin as candidate for supportive treatment of severe COVID-19.
Hannelore Ehrenreich,Karin Weissenborn,Martin Begemann,Martin Begemann,Markus Busch,Eduard Vieta,Kamilla W. Miskowiak +6 more
TL;DR: Evidence that supports the use of human recombinant erythropoietin (EPO) for ameliorating course and outcome of seriously ill COVID-19 patients is recap here and the research design for a double-blind placebo-controlled randomized clinical trial including severely affected patients is planned to start shortly.
Journal ArticleDOI
Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?
TL;DR: The objective of this study was to establish a baseline for the evaluation of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis.
Journal ArticleDOI
COVID-19-associated pulmonary and cerebral thromboembolic disease
TL;DR: A case of a 79-year-old woman that presented with stroke and was found to have COVID-19 pneumonia and concomitant large burden pulmonary arterial clot is reported.
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