Journal ArticleDOI
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
TLDR
An unsuspected abnormality in all cells from the nine patients with chronic myelogenous leukaemia has been detected with quinacrine fluorescence and various Giemsa staining techniques, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and thelong arm of 9, producing the 9q+ chromosome.Abstract:
CELLS from nine consecutive patients with chronic myelogenous leukaemia (CML) have been analysed with quinacrine fluorescence and various Giemsa staining techniques. The Philadelphia (Ph1) chromosome in all nine patients represents a deletion of the long arm of chromosome 22 (22q−)1,2. An unsuspected abnormality in all cells from the nine patients has been detected with these new staining techniques. It consists of the addition of dully fluorescing material to the end of the long arm of one chromosome 9 (9q+). In Giemsa-stained preparations, this material appears as an additional faint terminal band in one chromosome 9. The amount of additional material is approximately equal to the amount missing from the Ph1 (22q−) chromosome, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and the long arm of 9, producing the 9q+ chromosome.read more
Citations
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Journal ArticleDOI
Translocation renal cell carcinoma: lack of negative impact due to lymph node spread.
James I. Geller,Pedram Argani,Adebowale Adeniran,Edith Hampton,Angelo M. De Marzo,Jessica Hicks,Margaret H. Collins +6 more
TL;DR: Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC, and characterization of the unique biological and clinical features of pediatric RCC are required.
Journal ArticleDOI
Recurrent chimeric fusion RNAs in non-cancer tissues and cells
Mihaela Babiceanu,Fujun Qin,Zhongqiu Xie,Yuemeng Jia,Kevin Lopez,Nick Janus,Loryn Facemire,Shailesh Kumar,Yuwei Pang,Yanjun Qi,Iulia M. Lazar,Hui Li +11 more
TL;DR: Performing functional analyses on a few widely expressed fusions found that silencing them resulted in dramatic reduction in normal cell growth and/or motility, and explored the implications of these non-pathological fusions in cancer and in evolution.
Book ChapterDOI
The viral and cellular forms of the Abelson (abl) oncogene.
Naomi Rosenberg,Owen N. Witte +1 more
TL;DR: Relatively little can be said to explain the preferential growth stimulation for certain hematopoietic cell types by the viral and other altered form of the oncogene, and no clear insights into the function of the normal cellular forms of the abl oncogenic are available.
Journal ArticleDOI
Genomic mechanisms and measurement of structural and numerical instability in cancer cells
Jane Bayani,Shamini Selvarajah,Georges Maire,Bisera Vukovic,Khaldoun Al-Romaih,Maria Zielenska,Jeremy A. Squire,Jeremy A. Squire +7 more
TL;DR: This work proposes the term structural chromosomal instability [(S)-CIN] to distinguish numerical from structural CIN, and describes the excessive rate of numerical and structural genomic change in tumors.
Journal ArticleDOI
Detection of chimeric BCR-ABL genes on bone marrow samples and blood smears in chronic myeloid and acute lymphoblastic leukemia by in situ hybridization
Martin Bentz,Georges Cabot,Marion Moos,Michael R. Speicher,Arnold Ganser,Peter Lichter,Hartmut Döhner +6 more
TL;DR: In this article, fluorescence in situ hybridization (FISH) was used to detect the presence of BCR-ABL fusion genes in patients with chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL).
References
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Journal ArticleDOI
New Technique for Distinguishing between Human Chromosomes
TL;DR: It seems probable, therefore, that the darker staining with Giemsa of these regions, after denaturation and annealing, indicates the presence of highly repetitive DNA.
Journal ArticleDOI
Technique for Identifying Y Chromosomes in Human Interphase Nuclei
TL;DR: This work investigated the possibility of positively identifying male nuclei in interphase by virtue of this staining property of the Y chromosome using quinacrine dihydro-chloride.
Journal ArticleDOI
Clinical Implications of Cytogenetic Variants in Chronic Myelocytic Leukemia (CML)
TL;DR: The development of other chromosomal abnormalities in Ph1 positive patients presaged the terminal stage of the disease.
Journal ArticleDOI
Philadelphia-Chromosome-Positive and -Negative Chronic Myelocytic Leukemia
TL;DR: Chromosomal studies were performed on 61 adult patients with "typical chronic myelocytic leukemia" and the Philadelphia (Ph1) chromosome was found in 43 patients, with equal sex distribution a year after diagnosis.
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