Journal ArticleDOI
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
TLDR
An unsuspected abnormality in all cells from the nine patients with chronic myelogenous leukaemia has been detected with quinacrine fluorescence and various Giemsa staining techniques, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and thelong arm of 9, producing the 9q+ chromosome.Abstract:
CELLS from nine consecutive patients with chronic myelogenous leukaemia (CML) have been analysed with quinacrine fluorescence and various Giemsa staining techniques. The Philadelphia (Ph1) chromosome in all nine patients represents a deletion of the long arm of chromosome 22 (22q−)1,2. An unsuspected abnormality in all cells from the nine patients has been detected with these new staining techniques. It consists of the addition of dully fluorescing material to the end of the long arm of one chromosome 9 (9q+). In Giemsa-stained preparations, this material appears as an additional faint terminal band in one chromosome 9. The amount of additional material is approximately equal to the amount missing from the Ph1 (22q−) chromosome, suggesting that there may be a hitherto undetected translocation between the long arm of 22 and the long arm of 9, producing the 9q+ chromosome.read more
Citations
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Journal ArticleDOI
Chronic myeloid leukaemia as a model of disease evolution in human cancer.
Junia V. Melo,David J. Barnes +1 more
TL;DR: Chronic myeloid leukaemia can be considered as a paradigm for neoplasias that evolve through a multi-step process and one of the best examples of a disease that can be targeted by molecular therapy; however, the success of new 'designer drugs' is largely restricted to the chronic phase of the disease.
Journal ArticleDOI
Chromosome aberrations and cancer
TL;DR: The association of consistent chromosome aberrations with particular types of cancer has led to the identification of some of these genes and the elucidation of their mechanisms of action.
Journal ArticleDOI
Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment.
Ravi Bhatia,Melissa Holtz,Ning Niu,Rachel Gray,David S. Snyder,Charles L. Sawyers,Daniel A. Arber,Marilyn L. Slovak,Stephen J. Forman +8 more
TL;DR: Results indicate that inhibition of BCR/ABL tyrosine kinase activity by imatinib mesylate does not eliminate malignant primitive progenitors in CML patients.
Journal ArticleDOI
The mutation spectrum revealed by paired genome sequences from a lung cancer patient
William Lee,Zhaoshi Jiang,Jinfeng Liu,Peter M. Haverty,Yinghui Guan,Jeremy Stinson,Peng Yue,Yan Zhang,Krishna P. Pant,Deepali Bhatt,Connie Ha,Stephanie Johnson,Michael I. Kennemer,Sankar Mohan,Igor Nazarenko,Colin K. Watanabe,Andrew B. Sparks,David S. Shames,Robert Gentleman,Frederic J. de Sauvage,Howard M. Stern,Ajay Pandita,Dennis G. Ballinger,Radoje Drmanac,Zora Modrusan,Somasekar Seshagiri,Zemin Zhang +26 more
TL;DR: A comprehensive view of somatic alterations in a single lung tumour is presented, and the first evidence, to the authors' knowledge, of distinct selective pressures present within the tumour environment is provided.
Journal ArticleDOI
ErbB receptors: from oncogenes to targeted cancer therapies
Hongtao Zhang,Alan Berezov,Qiang Wang,Geng Zhang,Jeffrey A. Drebin,Ramachandran Murali,Mark I. Greene +6 more
TL;DR: Current therapy has not yet been optimized, allowing for opportunities for optimization of the next generation of targeted therapy, particularly with regards to inhibiting heteromeric ErbB family receptor complexes.
References
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Journal ArticleDOI
New Technique for Distinguishing between Human Chromosomes
TL;DR: It seems probable, therefore, that the darker staining with Giemsa of these regions, after denaturation and annealing, indicates the presence of highly repetitive DNA.
Journal ArticleDOI
Technique for Identifying Y Chromosomes in Human Interphase Nuclei
TL;DR: This work investigated the possibility of positively identifying male nuclei in interphase by virtue of this staining property of the Y chromosome using quinacrine dihydro-chloride.
Journal ArticleDOI
Clinical Implications of Cytogenetic Variants in Chronic Myelocytic Leukemia (CML)
TL;DR: The development of other chromosomal abnormalities in Ph1 positive patients presaged the terminal stage of the disease.
Journal ArticleDOI
Philadelphia-Chromosome-Positive and -Negative Chronic Myelocytic Leukemia
TL;DR: Chromosomal studies were performed on 61 adult patients with "typical chronic myelocytic leukemia" and the Philadelphia (Ph1) chromosome was found in 43 patients, with equal sex distribution a year after diagnosis.
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