malERA: An updated research agenda for malaria elimination and eradication.
Regina Rabinovich,Regina Rabinovich,Chris Drakeley,Abdoulaye A. Djimde,B. Fenton Hall,Simon I. Hay,Simon I. Hay,Janet Hemingway,David C. Kaslow,Abdisalan M. Noor,Abdisalan M. Noor,Fredros O. Okumu,Fredros O. Okumu,Fredros O. Okumu,Richard W. Steketee,Marcel Tanner,Timothy N. C. Wells,Maxine Whittaker,Elizabeth A. Winzeler,Dyann F. Wirth,Kate Whitfield,Pedro L. Alonso +21 more
TLDR
The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community’s ability to eradicate it globally.Abstract:
Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.read more
Citations
More filters
Journal ArticleDOI
Malaria eradication within a generation: ambitious, achievable, and necessary
Richard G A Feachem,Ingrid Chen,Omar S. Akbari,Amelia Bertozzi-Villa,Samir Bhatt,Fred Binka,Maciej F. Boni,Caroline O. Buckee,Joseph L Dieleman,Arjen M. Dondorp,Alex Eapen,Neelam Sekhri Feachem,Scott G. Filler,Peter W. Gething,Roly Gosling,Annie Haakenstad,Kelly Harvard,Arian Hatefi,Dean T. Jamison,Kate E. Jones,Corine Karema,Richard Nchabi Kamwi,Altaf A. Lal,Erika Larson,Margaret Lees,Neil F. Lobo,Angela E Micah,Bruno Moonen,Gretchen Newby,Xiao Ning,Muhammad Pate,Martha L Quiñones,Michelle E. Roh,Ben Rolfe,Dennis Shanks,Balbir Singh,Kenneth Staley,James Tulloch,Jennifer Wegbreit,Hyun Ju Woo,Winnie Mpanju-Shumbusho +40 more
TL;DR: Authors: Richard G. A. Feachem, Ingrid Chen*, Omar Akbari‡, Amelia Bertozzi-Villa, Samir Bhatt, Fred Binka, Maciej Boni, Caroline Buckee, Joseph Dieleman, Arjen Dondorp, Neelam Sekhri FeAChem, Scott Filler, Peter Gething, Roly Gosling, Annie Haakenstad.
Journal ArticleDOI
Engineering a Rugged Nanoscaffold to Enhance Plug-and-Display Vaccination
TL;DR: SpyCatcher-mi3 nanoparticles showed high stability to temperature, freeze–thaw, lyophilization, and storage over time, and should facilitate broad application for nanobiotechnology and vaccine development.
Journal ArticleDOI
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY.
Jane F. Armstrong,Elena Faccenda,Simon D. Harding,Adam J. Pawson,Christopher Southan,Joanna L. Sharman,Brice Campo,David R. Cavanagh,Stephen P.H. Alexander,Anthony P. Davenport,Michael Spedding,Jamie A. Davies,Nc-Iuphar +12 more
TL;DR: The IUPHAR/BPS Guide to PHARMACOLOGY is an open-access, expert-curated database of molecular interactions between ligands and their targets that provides new pharmacological content, including molecular targets in the malaria parasite, interaction data for ligands with antimalarial activity, and establishes curation of data from screening assays.
Journal ArticleDOI
Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.
Nicanor Obaldia,Nicanor Obaldia,Elamaran Meibalan,Elamaran Meibalan,Juliana M. Sá,Siyuan Ma,Martha A. Clark,Pedro Mejia,Roberto R. Moraes Barros,William Otero,Marcelo U. Ferreira,James R. Mitchell,Danny A. Milner,Curtis Huttenhower,Dyann F. Wirth,Manoj T. Duraisingh,Thomas E. Wellems,Matthias Marti,Matthias Marti +18 more
TL;DR: It is suggested that the bone marrow is an important reservoir for gametocyte development and proliferation of malaria parasites, and a systematic examination of tissue sequestration during P. vivax infection has important implications for parasite diagnosis and treatment.
Journal ArticleDOI
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.
Alison Roth,Steven P. Maher,Steven P. Maher,Amy J. Conway,Ratawan Ubalee,Victor Chaumeau,Victor Chaumeau,Chiara Andolina,Chiara Andolina,Stephen A. Kaba,Amélie Vantaux,Malina A. Bakowski,Richard Thomson-Luque,Swamy R. Adapa,Naresh Singh,Samantha J. Barnes,Caitlin A. Cooper,Mélanie Rouillier,Case W. McNamara,Sebastian A. Mikolajczak,Noah Sather,Benoît. Witkowski,Brice Campo,Stefan H. I. Kappe,David E. Lanar,François Nosten,François Nosten,Silas A. Davidson,Rays H. Y. Jiang,Dennis E. Kyle,Dennis E. Kyle,John H. Adams +31 more
TL;DR: Primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens and can be implemented in laboratories in disease-endemic areas to accelerate vaccine and drug discovery research.
References
More filters
Journal ArticleDOI
Dilemmas in a general theory of planning
TL;DR: The search for scientific bases for confronting problems of social policy is bound to fail, becuase of the nature of these problems as discussed by the authors, whereas science has developed to deal with tame problems.
Journal ArticleDOI
The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015
Samir Bhatt,Daniel J. Weiss,Ewan Cameron,Donal Bisanzio,Bonnie Mappin,Ursula Dalrymple,Katherine E. Battle,Catherine L. Moyes,Andrew J. Henry,Philip A. Eckhoff,Edward Allen Wenger,Olivier J T Briët,Olivier J T Briët,Melissa A. Penny,Melissa A. Penny,Thomas J. Smith,Thomas J. Smith,Adam Bennett,Joshua Yukich,Thomas P. Eisele,Jamie T. Griffin,Cristin A Fergus,Michael Lynch,Finn Lindgren,Justin M. Cohen,C L J Murray,David L. Smith,Simon I. Hay,Simon I. Hay,Simon I. Hay,Richard E Cibulskis,Peter W. Gething +31 more
TL;DR: It is found that Plasmodium falciparum infection prevalence in endemic Africa halved and the incidence of clinical disease fell by 40% between 2000 and 2015, and interventions have averted 663 (542–753 credible interval) million clinical cases since 2000.
Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frédéric Ariey,Benoit Witkowski,Chanaki Amaratunga,Johann Beghain,Anne-Claire Langlois,Nimol Khim,Saorin Kim,Valentine Duru,Christiane Bouchier,Laurence Ma,Pharath Lim,Rithea Leang,Socheat Duong,Sokunthea Sreng,Seila Suon,Char Meng Chuor,Denis Mey Bout,Sandie Menard,William O. Rogers,Blaise Genton,Thierry Fandeur,Olivo Miotto,Pascal Ringwald,Jacques Le Bras,Antoine Berry,Jean Christophe Barale,Rick M. Fairhurst,Françoise Benoit-Vical,Odile Mercereau-Puijalon,Didier Menard +29 more
TL;DR: Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance.
Journal ArticleDOI
A Group Process Model for Problem Identification and Program Planning
TL;DR: A group process approach useful for practicing administrators charged with a program development task is set forth, suggested for involving the following critical reference groups in successive phases of program development.
Related Papers (5)
The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015
Samir Bhatt,Daniel J. Weiss,Ewan Cameron,Donal Bisanzio,Bonnie Mappin,Ursula Dalrymple,Katherine E. Battle,Catherine L. Moyes,Andrew J. Henry,Philip A. Eckhoff,Edward Allen Wenger,Olivier J T Briët,Olivier J T Briët,Melissa A. Penny,Melissa A. Penny,Thomas J. Smith,Thomas J. Smith,Adam Bennett,Joshua Yukich,Thomas P. Eisele,Jamie T. Griffin,Cristin A Fergus,Michael Lynch,Finn Lindgren,Justin M. Cohen,C L J Murray,David L. Smith,Simon I. Hay,Simon I. Hay,Simon I. Hay,Richard E Cibulskis,Peter W. Gething +31 more