Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
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Journal ArticleDOI
The effect of C-terminal fragment of JNK2 on the stability of p53 and cell proliferation.
TL;DR: It was shown that C-JNK fragment could form complex with p53 both in vivo and in vitro, and can increase p53 stability by inhibiting p53 ubiquitination.
Dissertation
Identification of in vivo interactions of insulin receptor substrate 1 in murine liver
TL;DR: Findings strongly suggest that not only PKC-, but also QSK-mediated regulation of insulin signaling at the level of IRS1 may contribute to insulin resistance upon diet-induced obesity.
Book ChapterDOI
Dual-Specificity Map Kinase (MAPK) Phosphatases (MKPs) and Their Involvement in Cancer
TL;DR: Current understanding of the role(s) that DUSPs or MKPs might play in the oncogenic process and suggests avenues for further studies are summarized and suggested.
Journal ArticleDOI
Opposite effects of cis-parinaric acid on activities of p38 MAPK and c-Jun N-terminal kinases in malignant rat astrocytoma cells
TL;DR: In vitro glioma exposure to cPNA at concentrations toxic to 36B10 but normal astrocyte results in a greater than 50% decrease in p38 MAPK activity, which implies that a persistent increase in JNK activity and protein is required for cytotoxicity of cP NA in malignant glial cells.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.