Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
Reads0
Chats0
TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
More filters
Journal ArticleDOI
Signal transduction and the u-PA/u-PAR system
Journal ArticleDOI
Involvement of p42/p44 MAPK, p38 MAPK, JNK, and NF-κB in IL-1β-induced VCAM-1 expression in human tracheal smooth muscle cells
Chien-Chun Wang,Wei-Ning Lin,Chiang-Wen Lee,Chih-Chung Lin,Shue-Fen Luo,Jong-Shyan Wang,Chuen-Mao Yang +6 more
TL;DR: Interleukin-1β has been shown to induce the expression of adhesion molecules on airway epithelial and smooth cells and contributes to inflammatory responses.
Journal ArticleDOI
Cytokines differentially regulate ICAM-1 and VCAM-1 expression on human gingival fibroblasts.
TL;DR: The results of this study mean that the balance of cytokines in periodontally diseased tissue may be essential for control of ICAM‐1 and VCAM‐ 1 expression on HGF, and the balance might be important for regulation of leucocytes infiltration and retention in Periodontally Diseased tissue.
Journal ArticleDOI
Cytoskeleton Reorganization Induces the Urokinase-type Plasminogen Activator Gene via the Ras/Extracellular Signal-regulated Kinase (ERK) Signaling Pathway
TL;DR: The results suggest that cells sense changes in cell morphology using the cytoskeleton as a sensor and respond by activating the ERK-involving signaling pathway from within the cell.
Journal ArticleDOI
Testicular germ cell apoptosis in Bcl6-deficient mice.
Satoko Kojima,Masahiko Hatano,Seiji Okada,Tetsuya Fukuda,Yoshiro Toyama,Shigeki Yuasa,Haruo Ito,Takeshi Tokuhisa +7 more
TL;DR: Treatment of testes of adult Bcl6+/+ mice with a mild hyperthermia resulted in germ cell apoptosis predominantly in metaphase I spermatocytes with induction of Bax protein and activation of p38 MAP kinase and this apoptosis mimics that in adult B cl6-/- mice.
References
More filters
Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.