Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
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Mécanismes moléculaires de l'induction de l'apoptose par le choc thermique chez les cellules de l'ovaire du hamster chinois surexprimant la p-glycoprotéine
TL;DR: In this paper, the authors investigate the possibilite de l'induction of l'apoptose chez des cellules de a hamster chinois surexprimant the proteine MDR (CHO MDR CHRC5) and des parentales ne developpant pas the resistance pleiotropique aux medicaments (CHO AuxB1) par le choc thermique.
Book ChapterDOI
Signal Transduction: Protein Phosphorylation and the Regulation of Insulin Secretion
TL;DR: This chapter focuses on the regulated protein serine/threonine kinases, which may be involved in insulin secretion, and discusses whether protein tyrosine kinase and phosphoprotein phosphatases play important roles in β-cell responses.
Mixed lineage kinase 3 signaling in ovarian cancer and neurofibromatosis-2
TL;DR: Using nanofiltration membranes for the recovery of phosphorous with a second type of technology is suggest to be a viable process, but the technology is still in its infancy.
Book ChapterDOI
OBSOLETE: Cell Signaling and Translational Developmental Therapeutics
Paul Dent,Амелічева Л.П. +1 more
TL;DR: In this article, the authors discuss cellular signaling in isolation and as it relates to extant single and combined therapeutic drug interventions, leading to a hypothetical series standardized sequential approaches describing a rigorous concept to drug development and clinical translation.
Journal ArticleDOI
A Stress Hub in Scedosporium apiospermum: The High Osmolarity Glycerol (HOG) Pathway
TL;DR: In this article , the authors show that a wide range of stress distinctively activates the High Osmolarity Glycerol (HOG) pathway in Scedosporium, including oxidants, menadione, cumene hydroperoxide, diamide, paraquat, and honokiol.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.