Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
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Journal ArticleDOI
The opioidergic system: potential roles and therapeutic indications in the eye.
Shahid Husain,David E. Potter +1 more
TL;DR: An overview of the complexity of opioid receptor-mediated pharmacologic actions in the eye is provided and evidence suggests that opioidergic ligands have the potential to protect against retinopathies, particularly those associated with glaucoma.
BookDOI
ErbB Receptor Signaling
TL;DR: The ErbB receptor family, also known as the EGF receptor family or type I receptorfamily, includes the epidermal growth factor (EGF) receptor (EGFR), which has been the primary choices as targets for developing cancer therapies.
Journal ArticleDOI
Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.
Yuki Kanda,Ryosuke Satoh,Saki Matsumoto,Chisato Ikeda,Natsumi Inutsuka,Kanako Hagihara,Sumio Matzno,Sho Tsujimoto,Ayako Kita,Reiko Sugiura +9 more
TL;DR: Spatial regulation of MAPKKK proteins remains poorly characterized in fission yeast, and Skb5 spatially regulates this process by downregulating Mkh1 localization to cell tips through its interaction with the SH3 domain.
Dissertation
Contribution à l'étude du cycle de la cellule endothéliale cornéenne humaine
TL;DR: In this paper, an outil innovant de mesure combinant un triple marquage Hoechst/Ethidium/Calceine AM was proposed for the analysis of pan-endothelium pan-corneenne.
Journal ArticleDOI
Effect of Hydrophobicity of PEO–PPO–PEO Block Copolymers on Micellization and Solubilization of a Model Drug Nimesulide
TL;DR: In this paper, the authors explored the molecular implications governing the solubilization of a model drug nimesulide (NIM) in micelles of ethylene oxide-propylene oxide (EO-PO) triblock copolymers.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.