Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Journal ArticleDOI
Activation of B-Raf and Regulation of the Mitogen-activated Protein Kinase Pathway by the Go α chain
TL;DR: The results suggest that Galpha(o) can regulate the MAPK pathway by activating B-Raf through a mechanism that requires a concomitant signal from tyrosine kinase receptors or Ras to efficiently stimulate MAPK activity.
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PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.
TL;DR: EA3 is capable of transactivating the Muc4/SMC promoter in a dose-dependent manner via direct attachment to a PEA3 binding site, and is potentiated by Ras and MEKK1 kinases.
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Tyrosine phosphorylation of extracellular signal-regulated protein kinase 4 in response to growth factors.
TL;DR: It is found that ERK4 in rat PC12 pheochromocytoma cells can be immunoprecipitated by anti‐ERK antiserum R2 and this reagent is used to characterize this species further, revealing an additional member of the ERK family that is responsive to growth factors and that could play a distinct role in intracellular signaling.
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Downstream targets of let-60 Ras in Caenorhabditis elegans.
Béatrice Romagnolo,Min Jiang,Moni Kiraly,Carrie Breton,Rebecca Begley,John Wang,James Lund,Stuart K. Kim +7 more
TL;DR: DNA microarrays are used to identify 708 genes that change expression in response to activated let-60 Ras that carry out terminal effector functions leading to morphological change in Caenorhabditis elegans.
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Cloning and characterization of Xenopus Rsk2, the predominant p90 Rsk isozyme in oocytes and eggs.
Ramesh R. Bhatt,James E. Ferrell +1 more
TL;DR: It is demonstrated that p42 MAP kinase can activate recombinant RSk2 in vitro to a specific activity comparable to that found in Rsk2 that has been activated maximally in vivo.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
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cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
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Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
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Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.