Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Dissertation
Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
TL;DR: It is demonstrated that acute hypoxic exposure results in human PAFB proliferation, associated with increased p44/p42 – ERK 1/2 and JNK MAPKs and Smad protein activity was assessed using Western Blotting Techniques and Catch and Release® immunophoresis techniques.
DissertationDOI
Dissecting the molecular mechanisms regulating proliferation, antigen responsiveness, and differentiation of CD4⁺ T lymphocytes : a central role for the mammalian target of Rapamycin (mTor)
TL;DR: In a model of CD3-induced clonal anergy, it is shown that antigen responsiveness was uniquely regulated by an IL-2/IL-2R-induced signalling event, which indicates that proliferation and antigen responsiveness are independently regulated and that the latter specifically requires intact signalling through mTor, the mammalian target of Rapamycin.
Journal ArticleDOI
IGF-II Mediates Mitogenic Signaling in IGF-I-Resistant Efe Pygmy T-Cell Lines• 424
Mitchell E Geffner,Mitchell E Geffner,Mitchell E Geffner,Yutaka Hattori,Yutaka Hattori,Yutaka Hattori,Juan Vera,Juan Vera,Juan Vera,Robert C. Bailey,Robert C. Bailey,Robert C. Bailey,David W Golde,David W Golde,David W Golde +14 more
TL;DR: Results indicate that Efe Pygmy T-cells have intact IGF-II receptor expression and binding, and IGF- II signaling without type 1 IGF receptor activation is associated with tyrosine kinase activity and phosphorylation of intracellular proteins.
Journal ArticleDOI
Morphogenesis, or the weaving of Orpheus' net
TL;DR: Le bourgeon de membre est un tres puissant paradigme pour the comprehension des mecanismes de the morphogenese des membres et du cerveau.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.