Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
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Journal ArticleDOI
Antioxidant responses and cellular adjustments to oxidative stress.
Cristina Espinosa-Diez,Verónica Miguel,Daniela Mennerich,Thomas Kietzmann,Patricia Sánchez-Pérez,Susana Cadenas,Santiago Lamas +6 more
TL;DR: The role of crucial cellular nucleophiles, such as glutathione, and their capacity to interact with oxidants and to establish networks with other critical enzymes such as peroxiredoxins are focused on.
Journal ArticleDOI
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
D M Owens,Stephen M. Keyse +1 more
TL;DR: In this paper, a negative feedback control mechanism was proposed for mitogen-activated protein kinases (MAPKs) to regulate dephosphorylation of MAPKs in mammalian cells, which is mediated by differential expression and activities of a family of 10 dual-specificity (Thr/Tyr) MAPK phosphatases.
Journal ArticleDOI
Protein–protein interactions define specificity in signal transduction
Tony Pawson,Piers Nash +1 more
TL;DR: The underlying biochemical mechanisms through which specificity is generated during signal transduction are addressed, and the means by which signaling molecules may act in combination to generate complex biological responses are pursued.
Journal ArticleDOI
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer
Devarajan Karunagaran,E Tzahar,R R Beerli,Xiaomei Chen,D Graus-Porta,B J Ratzkin,Rony Seger,N E Hynes,Yosef Yarden +8 more
TL;DR: The results imply that ErbB‐2 is a pan‐ErbB subunit of the high affinity heterodimeric receptors for NDF and EGF, which may be due to its ability to potentiate in trans growth factor signaling.
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The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway
TL;DR: It is demonstrated that yan can repress transcription and that this repression activity is negatively regulated by the Ras1/MAPK signal, most likely through direct phosphorylation of yan by MAPK.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
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cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
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Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.