Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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A Systemic Administration of NMDA Induces Immediate Early Gene pip92 in the Hippocampus
Kwang Chul Chung,Song Woo Shin,Song Woo Shin,Song Woo Shin,Min Yoo,Min-Young Lee,Hyun Woo Lee,Byung Kil Choe,Young Soo Ahn +8 more
TL;DR: It is demonstrated that pip92 is expressed in the mouse brain after a single intraperitoneal injection of NMDA, and it is suggested that pip 92 is likely to play an important role in neuronal cell death induced by excitotoxic NMDA injury in the CNS.
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Expression of HopAI interferes with MAP kinase signalling in Magnaporthe oryzae
TL;DR: Mps1 is the major intracellular target of HopAI when it is overexpressed, and MAP kinase signalling is important for cell-to-cell movement of invasive hyphae in M. oryzae.
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PI3K and ERK 1‐2 regulate early stages during head regeneration in hydra
TL;DR: Evidence is presented for the participation of a third pathway, the PI3K‐PKB pathway, involved in the regeneration of the head in hydra and the specific developmental point regulated by them appears to be the commitment of tissue at the apical end of the regenerate to form the head organizer.
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Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers
TL;DR: In this article, a literature review of the mechanisms of Ras signaling in the MAPK pathway and its possible oncogenic mutations, illustrate how specific mutations affect the pathogenesis of specific cancers, and compare available and in-development treatments targeting the Ras pathway.
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Dual function of Ras in Raf activation.
TL;DR: It is demonstrated that the role of Ras1 in Draf activation is not limited to the translocation of Draf to the membrane through a Ras1-Draf association, and that Ras1 is essential for the activation of an additional factor which in turn activates Draf.
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Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
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cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
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Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
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Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.