Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Ras effectors and their role in mitogenesis and oncogenesis
Tom Joneson,Dafna Bar-Sagi +1 more
TL;DR: This review provides an account of the target proteins that interact with Ras and the functional consequences of these interactions, and the relative contribution of the different Ras effector pathways to the mitogenic and oncogenic effects of Ras.
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Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways.
Shin Onodera,Jun Nishihira,Kazuya Iwabuchi,Yoshikazu Koyama,Kazuhiko Yoshida,Sakae Tanaka,Akio Minami +6 more
TL;DR: This paper showed that macrophage migration inhibitory factor (MIF) up-regulated MMP-13 mRNA of rat calvaria-derived osteoblasts, reaching the maximum level at 6-12 hours and returning to the basal level at 36 hours.
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ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network
Ronit Pinkas-Kramarski,Maya Shelly,Bradley C. Guarino,Ling Mei Wang,Ljuba Lyass,Iris Alroy,Mauricio Alamandi,Angera H. Kuo,James D. Moyer,Sara Lavi,Miriam Eisenstein,Barry J. Ratzkin,Rony Seger,Sarah S. Bacus,Jacalyn H. Pierce,Glenn C. Andrews,Yosef Yarden +16 more
TL;DR: It is concluded that the NRG-ErbB network represents a complex and nonredundant machinery developed for fine-tuning of signal transduction.
Journal ArticleDOI
SMK1, a developmentally regulated MAP kinase, is required for spore wall assembly in Saccharomyces cerevisiae.
TL;DR: It is proposed that the SMK1 MAP kinase participates in a developmentally regulated signal transduction pathway that coordinates cytodifferentiation events with the transcriptional program.
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Murine Ksr interacts with MEK and inhibits Ras-induced transformation
A. Denouel-Galy,E.M. Douville,Patricia H. Warne,Catherine Papin,D Laugier,Georges Calothy,Julian Downward,Alain Eychène +7 more
TL;DR: A novel mechanism for Ksr in regulating the MAP kinase pathway is suggested, at least in part through an ability to interact with MEK.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
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cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
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Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.