Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
Reads0
Chats0
TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
More filters
Journal ArticleDOI
Nuclear Mitogen-activated Protein Kinase Activation by Protein Kinase Cζ during Reoxygenation after Ischemic Hypoxia
Yoichi Mizukami,Sei Kobayashi,Florian Überall,Karina Hellbert,Nobuyuki Kobayashi,Ken-ichi Yoshida +5 more
TL;DR: Observations indicate that PKCζ, which is activated by phosphoinositide 3-kinase, induces MAPK activation through MEK in the nucleus during reoxygenation after ischemic hypoxia.
Journal ArticleDOI
Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.
TL;DR: Ste4 contains a leucine zipper and is capable of homotypic interaction and has regions of homology with STE50, an S. cerevisiae protein required for sexual differentiation that it is shown can bind to STE11.
Journal ArticleDOI
Reversion of Ras- and Phosphatidylcholine-hydrolyzing Phospholipase C-mediated Transformation of NIH 3T3 Cells by a Dominant Interfering Mutant of Protein Kinase C λ Is Accompanied by the Loss of Constitutive Nuclear Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Activity
TL;DR: It is reported here that extracellular signal-regulated kinase (ERK)-1 and −2 are constitutively activated in v-Ras- and PC-PLC-transformed cells in the absence of added growth factors.
Journal ArticleDOI
Integrin β1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo
TL;DR: In vitro analysis revealed that integrin β1 is required for cell adhesion, cell spreading and invasion, but not for cell growth or activation of FAK and ERK signalling in vitro or in vivo, and stably knocked-down integrinβ1 expression in the VSCC cell line A431 confirmed this.
Journal ArticleDOI
Involvement of p42/p44 MAPK, JNK, and NF-kappaB in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells.
TL;DR: Activation of p42/p44 MAPK and JNK cascades, at least in part, mediated through NF‐κB pathway is essential for IL‐1β‐induced ICAM‐1 gene expression in A549 cells, providing new insight into the mechanisms of IL-1β action that cytokines may promote inflammatory responses in the airway disease.
References
More filters
Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.