Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue
TL;DR: Using modified JNK and its ATP analogue enables the detection of novel JNK substrates, including heterogeneous nuclear ribonucleoprotein K, which is involved in transcription and post-transcriptional mRNA metabolism.
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Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
Koji Sayama,Yasushi Hanakawa,Yuji Shirakata,Kenshi Yamasaki,Yasuhiro Sawada,Lin Sun,Kiyofumi Yamanishi,Hidenori Ichijo,Koji Hashimoto +8 more
TL;DR: It is proposed that the ASK1-p38 MAP kinase cascade is a new intracellular regulator of keratinocyte differentiation.
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ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway.
TL;DR: Assessment of the role of RTKs in ARIA signaling found that synaptic induction of AChR genes requires activation of both Ras/MAPK and PI3K signal transduction pathways.
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Cloning and characterization of a member of the MST subfamily of Ste20-like kinases.
TL;DR: A second human homology of the yeast Ste20 protein kinase family is identified, which is most similar to the previously identified MST1 protein kinases, which suggests that there may be subfamilies of Ste20-likeprotein kinases and that MST2 may define one of these subfam families.
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Routing MAP kinase cascades
TL;DR: In her Perspective, Elion discusses new results in this issue by Whitmarsh et al. and Schaeffer et al., who identify proteins that act as scaffolds in mouse cells, binding certain kinases to make a pathway for a specific function that is insulated from the rest of the cell.
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Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
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cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
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Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
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Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.