Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
More filters
Posted ContentDOI
Structural Insights into the BRAF Monomer-to-dimer Transition Mediated by RAS Binding
TL;DR: In this paper, the RAS binding domain (RBD) of BRAF was resolved in the autoinhibited structures, and it was shown that neither MEK nor ATP binding is required to stabilize the auto-inhibited complexes.
Journal ArticleDOI
[Genomic organization and promoter analysis of mouse apoptosis signal-regulating kinase 2 (ASK 2)].
TL;DR: Results suggest that expression of mouse ASK 2 is regulated by multiple mechanisms, including a strong suppressive element in the 5'-flanking region of the promoter.
Modeling Virus-Host Networks
TL;DR: HIV-human protein interactions can be predicted using documented human peptide motifs found to be conserved on HIV proteins from different subtypes, and human proteins predicted to bind to HIV proteins are enriched in both documented HIV targeted proteins and pathways known to be utilized by HIV.
effects on mitogenesis, in vascular smooth muscle cells MEK inhibition augments Raf activity, but has variable
TL;DR: This article cites€30 articles, 21 of which you can access for free at: http://ajpcell.physiology.org/content/274/6/C1521.full found at: Additional material and information about American Journal of Physiology - Cell Physiology can behttp://www.the-aps.org/.
References
More filters
Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.