Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
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Journal ArticleDOI
Gα12 and Gα13 Regulate Extracellular Signal-regulated Kinase and c-Jun Kinase Pathways by Different Mechanisms in COS-7 Cells
TL;DR: Different mechanisms mediate two effects of Gα12 and Gα13: the ERK pathway inhibition is mediated at the level of MAP kinase kinase in a Ras- and Raf-independent fashion, whereas the JNK pathway stimulation is mediated by Cdc42.
Journal ArticleDOI
Cooperation of p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways during Granulocyte Colony-stimulating Factor-induced Hemopoietic Cell Proliferation
TL;DR: It is shown that two distinct cytoplasmic regions of the G-CSF receptor are involved in activation of the p38 pathway: a region within the 100 membrane-proximal amino acids is sufficient to induce low levels of p38 and MAP kinase-activated protein kinase 2 activation, whereas the membrane-distal phosphorylation site Tyr763 mediates strong activation of these kinases.
Journal ArticleDOI
N-methyl-D-aspartate (NMDA) and the regulation of mitogen-activated protein kinase (MAPK) signaling pathways: a revolving neurochemical axis for therapeutic intervention?
John J. Haddad,John J. Haddad +1 more
TL;DR: The purpose of this review is to discuss the role of MAPKs and their role in a plethora of cellular functions, how cellular signaling pathways, related cofactors and intracellular conditions affect NMDA-MAPK interactions and the role in pathophysiology and the evolution of disease conditions.
Journal ArticleDOI
The p38 MAP kinase inhibitor SB203580 enhances nuclear factor‐kappa B transcriptional activity by a non‐specific effect upon the ERK pathway
KU Birkenkamp,Leonore Tuyt,Chantal Lummen,Albertus T. J. Wierenga,Wiebe Kruijer,Edo Vellenga +5 more
TL;DR: It is demonstrated that the p38 MAP kinase pathway is not involved in the OA‐induced activation of NF‐κB, and the involvement of the ERK1/2 pathway in the enhancing effects of SB203580 on NF-κB‐mediated gene transcription is implicate.
Patent
Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
TL;DR: A compound of Formula (I): (I) salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.