Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Patent
Ras suppressor SUR-5
Trent Gu,Satoshi Orita,Min Han +2 more
TL;DR: In this article, the authors presented isolated nucleotide sequence encoding SUR-5, isolated SAR peptides, and antibodies that specifically bind SAR-5 for signal transduction detection and expression.
Dissertation
Regulation of vein, an activating ligand of the drosophila EGF receptor
TL;DR: This book aims to provide a history of skateboarding in the sport and some of the elements that contributed to its development have been described.
Recycling of HER-ErbB Receptors: Rescue From Apoptosis and Targets for Immunotherapy
TL;DR: Signals to multiply, migrate and outgrow blood vessels are mediated by growth factors of the EGF/neuregulin family, and activated growth factor receptors are modified by mono-ubiquitins rather than by poly-ubicuitylation.
Journal ArticleDOI
Afr1p mediates activation of the Slt2p MAP kinase induced by pheromone, heat shock and hypo-osmotic shock in Saccharomyces cerevisiae.
Mingyong Xiong,Jingyu Wang +1 more
TL;DR: Results indicated that, in addition to its role in establishing pheromone-induced morphogenesis, Afr1p may act as a 'sensor' to transduce cell wall stress resulting from different stimuli to the cell integrity pathway, leading to Slt2p activation.
Journal ArticleDOI
Explorations of the optimal method for isolating oocytes from zebrafish (Danio rerio) ovary.
TL;DR: Striking isolation is comparatively recommended as the optimum method for separating and collecting numerous intact and healthy zebrafish oocytes in vitro for the subsequent developmental research.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.