Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Implementing Non-Equilibrium Networks with Active Circuits of Duplex Catalysts
TL;DR: Active Circuits of Duplex Catalysts (ACDC) as discussed by the authors is a framework for constructing catalytic DSD networks, where double-stranded gate complexes are used to coordinate the catalysis, indirect interaction between the catalyst and its substrate, and recovery of a distinct strand from the one that triggered the reaction.
Posted ContentDOI
Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors
TL;DR: A synthetic fluorescent substrate for human MAPKs is engineered that relocates from the nucleus to the cytoplasm when phosphorylated by the kinase and provides a better sensitivity relative to other similar biosensors and has allowed the monitoring of ERK MAPK activity pulses upon a single physiological EGF stimulation.
Journal ArticleDOI
A potential protective role for thiamine in glucose-driven oxidative stress.
TL;DR: It is concluded that a defect in the glucose-sensing signaling pathway in ird11 mutants likely causes erroneous low glucose-Sensing signaling and high ATP production, which most likely occurs because high glucose availability in the medium induces an impairment in the respiratory chain and fermentation balance in these cells.
Minireview Simultaneous induction of stimulatory and inhibitory signals by PDGF
TL;DR: In this paper, the authors reported that at least 10 different SH2 domain molecules bind in a specific manner to 11 identified autophosphorylated tyrosine residues in the platelet-derived growth factor P-receptor, thereby initiating signaling pathways leading to cell growth and motility.
Dissertation
Regulation of cytokines by Tpl-2 in dendritic cells andmacrophages
TL;DR: Investigation of the role ERK has in regulating cytokine production in DC and macrophages shows that production of the suppressive cytokine IL-10 is reduced in response to TLR stimulation in macrophage and dendritic cells, and these findings have important implications for treatment of autoimmune diseases.
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.