Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Dissertation
Regulation of cell fate by phosphorylation : a tale of two transcription factors
TL;DR: There appears to be an emerging theme in which the transcription factor itself possesses a second, enzymatic function, which creates an entirely new set of regulatory mechanisms that emanate locally from the transcriptional complexes themselves.
Journal ArticleDOI
Charactersitics of gastroprotein synthesis and phosphorylation in human gastric carcinoma cells
E. I. Karakin,L. M. Nepomnyashchikh,K. V. Vardosanidze,Ya. Nekarda,Yu I Patyutko,G. I. Nepomnyashchikh,E. A. Suderevskii,V. V. Nechunaev,N. V. Adon'eva,S. V. Cheresiz,M. N. Bochkarev +10 more
TL;DR: Three classes of gastric tumors are distinguished according to the difference between tumor and normal cell polypeptides: I) no difference, II) isolated differences, and III) numerous qualitative and quantitative differences in gastropolypepides and their phosphoforms.
Osmoregulation at different stages of the yeast life cycle
TL;DR: Osmotic stress response is characterized using a conditional osmotic system and the importance of the Fps1 transmembrane core in restricting glycerol flux is described, and it is shown that the termini alone are not sufficient to regulate channel activity.
The Role of Anti- and Pro-apoptotic Cofactors in Hypoxia/Reoxygenation-Dependent Regulation of MAPKs in the Brain of an Anoxia-Tolerant Model
TL;DR: In this paper, the cellular and molecular regulation of MAPKs and apoptosis was investigated in a model of hypoxiatolerance of Chrysemys picta bellii, an anoxia-tolerant turtle.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.