Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Dissertation
Alteracions de la VIA RAS-RAF en càncer gastrointestinal amb defectes de reparació genòmica
TL;DR: En cancer colorectal (CCR) the mutacio puntual de BRAF V600E sassocia significativament als casos que presenten inestabilitat de microsatellits (MSI) que solen presentar mutacions per insercio o delecio a sequencies repetitives.
Journal ArticleDOI
Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells
Stanislava Sladeček,Katarzyna Anna Radaszkiewicz,Martina Bohmova,Tomáš Gybel,Tomasz Witold Radaszkiewicz,Jiří Pacherník +5 more
TL;DR: It is shown that even though DUSP7 knock-out ES cells do retain some of their basic characteristics, when it comes to differentiation, they preferentially differentiate towards neural cells, while the formation of early cardiac mesoderm is repressed.
Clock-Controlled Genes in Neurospora crassa.
TL;DR: This data indicates thatadian clock control of MAPK activity in the Eukaryotic Cell is driven by seasonal oscillations in the immune system, which is consistent with a “doping” mechanism.
From cell populations to single cells - quantitative analysis of osmotic regulation in yeast
TL;DR: This thesis investigated the quantitative aspects of yeast osmotic regulation, providing precise, time resolved information about the biophysical characteristics of osmosis, and provides new insight into the network properties of the HOG pathway.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.