Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
Citations
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Journal ArticleDOI
miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.
TL;DR: It is indicated that miR‐195 inhibited WT and L613V RAF‐1 induced hyperactive osteoblast differentiation in MC3T3‐E1 cells by targeting RAF‐ 1, and might be a novel therapeutic agent for the treatment of L613v‐induced bone deformity in Noonan syndrome.
Journal ArticleDOI
Disruption of brain MEK-ERK sequential phosphorylation and activation during midazolam-induced hypnosis in mice: Roles of GABAA receptor, MEK1 inactivation, and phosphatase MKP-3
TL;DR: The results indicate that during midazolam‐induced sleep in mice there is an uncoupling of p‐MEK (increased) to p‐ERK (decreased) signals, relevant for the neurobiology and clinical use of benzodiazepines.
Journal ArticleDOI
Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast.
Beatriz Vázquez,Teresa Soto,Javier Encinar del Dedo,Alejandro Franco,Jero Vicente,Elena Hidalgo,Mariano Gacto,José Cansado,Marisa Madrid +8 more
TL;DR: It is shown that a trapping mechanism increases MAPKK binding and tyrosine phosphorylation of both Sty1 and Pmk1 when subsequentosphorylation at threonine is hampered, indicating that a sequential and likely processive mechanism might be responsible for MAPK activation in this simple organism.
Book ChapterDOI
Control of Cell Polarity and Shape
Yi-Jun Sheu,Michael Snyder +1 more
TL;DR: Cell polarity results from asymmetric cell growth (polarized growth) and cell division from a specific plane ( polarized division), two phenomena fundamental for the development of organisms ranging from yeasts to humans.
Journal ArticleDOI
Tighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.
Masha Tesker,Sadiduddin Edbe Selamat,Jonah Beenstock,Ruchama Hayouka,Oded Livnah,David Engelberg,David Engelberg +6 more
TL;DR: A structural element termed ‘hydrophobic core’ is a suppressor of spontaneous autophosphorylation in Hog1 and p38s and is tighter in mammalian's p 38s.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.