Journal ArticleDOI
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase.
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TLDR
Recent advances have shown that in two MAP kinase pathways (the mating response pathway in the fission yeast Schizosaccharomyces pombe, and receptor tyrosine kinase signalling), the small GTP binding protein ras p21 links membrane events to kinase pathway activation.About:
This article is published in Current Opinion in Genetics & Development.The article was published on 1994-02-01. It has received 987 citations till now. The article focuses on the topics: MAP kinase kinase kinase & Mitogen-activated protein kinase kinase.read more
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Journal ArticleDOI
Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling
TL;DR: In this paper, a review of the role of growth factor-initiated signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases.
Book ChapterDOI
MAP kinases in plant signal transduction: how many, and what for?
TL;DR: Analysis of partial MAPK sequences from full length, truncated cDNAs and expressed sequence tags revealed the presence of two new subfamilies in the plant MAPK superfamily, and signature sequences valid for the superfamily of plantMAPKs and each subfamily were derived and should help in future classification of novel MAPKs.
Journal ArticleDOI
Activation of the cell wall integrity pathway promotes escape from G2 in the fungus Ustilago maydis.
Natalia Carbó,José Pérez-Martín +1 more
TL;DR: It is proposed that the process of cell cycle adaptation to cell stress evolved differently in these two divergent organisms so that each can move towards a cell cycle phase most appropriate for responding to the environmental signals encountered.
Journal ArticleDOI
p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180.
TL;DR: It is suggested that p38s are active when only the Thr residue of the phosphorylation lip is phosphorylated, similar to many other kinases in nature.
Journal ArticleDOI
Regulation of lymphocyte fate by Ras/ERK signals
TL;DR: Recent studies with lymphocytes have evoked a new idea that two types of interconnected mechanisms can contribute to the sensitivity and robustness of the ERK activity, and candidate immediate early genes that regulate lymphocyte proliferation and differentiation have emerged.
References
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Journal ArticleDOI
Mammalian Ras interacts directly with the serine/threonine kinase Raf
TL;DR: Raf interacts with wild-type and activated Ras, but not with an effector domain mutant of Ras or with a dominant-interfering Ras mutant, and this interaction is dependent on GTP bound to Ras.
Journal ArticleDOI
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Teri G. Boulton,Steven H. Nye,David J. Robbins,Nancy Y. Ip,Elizabeth Radzlejewska,Sharon D. Morgenbesser,Ronald A. DePinho,Nikos Panayotatos,Melanie H. Cobb,George D. Yancopoulos +9 more
TL;DR: Cl cloning and characterization of two ERK1-related kinases, ERK2 and ERK3, are described and evidence suggesting that there are additional ERK family members is provided, which may serve as intermediates that depend on tyrosine phosphorylation to activate serine/threonineosphorylation cascades.
Journal ArticleDOI
cPLA2 is phosphorylated and activated by MAP kinase.
TL;DR: Treatment of cells with agents that stimulate the release of arachidonic acid causes increased serine phosphorylation and activation of cytosolic phospholipase A2 (cPLA2).
Journal ArticleDOI
Phosphorylation of c- jun mediated by MAP kinases
TL;DR: Evidence is presented that mitogen-activated protein-serine (MAP) kinases (pp54 and pp42/44) specifically phosphorylate these sites and that their phosphorylation positively regulates the transacting activity of c-jun.
Journal ArticleDOI
Raf-1 activates MAP kinase-kinase.
John M. Kyriakis,Harald App,Xian-feng Zhang,Papia Banerjee,David L. Brautigan,Ulf R. Rapp,Joseph Avruch +6 more
TL;DR: Results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo, the first physiological substrate of the c-raf-l protooncogene product to be identified.