Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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Journal ArticleDOI
[Astrocytes and microglia: active players in synaptic plasticity].
TL;DR: How glia modulates synaptic plasticity focusing on long-term potentiation and depression is discussed, and the role of the signaling processes between astrocytes and microglia in these mechanisms is questioned.
Journal ArticleDOI
BDNF Met allele Is Associated With Lower Cognitive Function in Poststroke Rehabilitation
Zhenxiang Han,Zhenxiang Han,Lili Qi,Qinfeng Xu,Mingzhu Xu,Mingzhu Xu,Lei Cai,John B. Wong,Xinjia Hu,Xinjia Hu,Xun Luo,Jiening Wang,Yuling Zhang,Yuling Zhang,Yapeng Li,Qing Mei Wang,Qing Mei Wang +16 more
TL;DR: A significant correlation between Met alleles and lower cognitive function at discharge in both ischemic and hemorrhagic stroke patients was detected and the BDNF genotype may be a useful predictor of cognitive function in inpatient poststroke rehabilitation.
Journal ArticleDOI
Prenatal intimate partner violence exposure predicts infant biobehavioral regulation: Moderation by the brain-derived neurotrophic factor (BDNF) gene.
Cecilia Martinez-Torteya,Caleb J. Figge,Michelle Gilchrist,Maria Muzik,Anthony P. King,Matthew Sorenson +5 more
TL;DR: The brain-derived neurotrophic factor Val66Met gene (BDNF) was evaluated as a moderator of the effect of prenatal IPV exposure on infant temperamental and cortisol regulation in response to a psychosocial challenge and significant genetic moderation effects were found.
Journal ArticleDOI
Acute Forced Exercise Increases Bdnf IV mRNA and Reduces Exploratory Behavior in C57BL/6J Mice
TL;DR: A single bout of exercise increases Bdnf IV mRNA in an intensity‐dependent manner; however, high‐intensity running reduces exploratory behavior in C57BL/6J mice.
Journal ArticleDOI
Transactivation of TrkB Receptors by Oxytocin and Its G Protein-Coupled Receptor
Mariela Mitre,Khalil Saadipour,Kevin W. Williams,Latika Khatri,Robert C. Froemke,Moses V. Chao +5 more
TL;DR: It is reported that the brain neuropeptide oxytocin increases BDNF TrkB activity in primary cortical neurons and in the mammalian neocortex during postnatal development, implying that oxytoc in may rely upon crosstalk with BDNF signaling to facilitate its actions through receptor transactivation.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.