Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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The Model of Aging Acceleration Network Reveals the Correlation of Alzheimer’s Disease and Aging at System Level
TL;DR: An aging predictor and an AD predictor using machine learning techniques are developed to provide insights into genes associated with AD and indicated that aging may contribute to the development of AD by affecting the function of the immune system and the energy metabolism process, where theimmune system may play a more prominent role in AD.
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Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.
Takeshi Uemura,Emi Suzuki-Kouyama,Shiori Kawase,Taiga Kurihara,Misato Yasumura,Tomoyuki Yoshida,Shu Fukai,Maya Yamazaki,Pengge Fei,Manabu Abe,Masahiko Watanabe,Kenji Sakimura,Masayoshi Mishina,Katsuhiko Tabuchi +13 more
TL;DR: In this article , the axons of cultured Nrxn TKO CGCs that are not in contact with a postsynaptic structure were found to have defects in the formation of presynaptic protein clusters and in action-potential-induced Ca2+ influxes.
Journal ArticleDOI
Preservation of spatial memory and neuroprotection by the fatty acid amide hydrolase inhibitor URB597 in a rat model of vascular dementia
TL;DR: In this article, the early effects of encephalomyosynangiosis (EMS) bypass surgery and augmented endocannabinoid signaling on CCH-induced cognitive dysfunction and neuronal damage were investigated.
Journal ArticleDOI
Serum and plasma levels of brain-derived neurotrophic factor in individuals with eating disorders (EDs): a systematic review and meta-analysis
Parnian Shobeiri,S. Bagherieh,Parsa Mirzayi,Amir Hossein Kalantari,Omid Mirmosayyeb,Antônio Lúcio Teixeira,Nima Rezaei +6 more
TL;DR: In this paper , the authors conducted a systematic search of the core electronic medical databases from inception to March 2022 and identified observational studies that compared individuals with EDs to controls without EDs on serum or plasma levels of BDNF.
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Innate chemical, but not visual, threat cues have been co‐opted as unconditioned stimulus for social fear learning in zebrafish
Julia S. Pinho,Julia S. Pinho,Marisa Castilho,Joao S. Sollari,Joao S. Sollari,Rui Filipe Oliveira,Rui Filipe Oliveira +6 more
TL;DR: This study found that only the chemical cue was effective in the social fear conditioning of zebrafish, and suggested that this differential efficacy of social cues results from the fact that the alarm cue is a more reliable indicator of threat, than the sight of an alarmed conspecific.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.