Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
Citations
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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Christiane D. Wrann,James P. White,John Salogiannnis,Dina Laznik-Bogoslavski,Jun Wu,Di Ma,Jiandie D. Lin,Michael E. Greenberg,Bruce M. Spiegelman +8 more
TL;DR: It is shown that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice.
Journal ArticleDOI
The Central Nervous System and the Gut Microbiome
TL;DR: The biological intersection of neurodevelopment and the microbiome is discussed and the hypothesis that gut bacteria are integral contributors to development and function of the nervous system and the balance between mental health and disease is explored.
Journal ArticleDOI
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.
Przemysław Kowiański,Grazyna Lietzau,Ewelina Czuba,Monika Waśkow,Aleksandra Steliga,Janusz Moryś +5 more
TL;DR: The importance of BDNF for future studies aimed at disclosing mechanisms of activation of signaling pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.
Journal ArticleDOI
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
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BDNF - a key transducer of antidepressant effects.
Carl Björkholm,Lisa M. Monteggia +1 more
TL;DR: Current data suggests that conventional antidepressants and ketamine mediate their antidepressant-like effects by increasing BDNF in forebrain regions, in particular the hippocampus, making BDNF an essential determinant of antidepressant efficacy.
References
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Journal ArticleDOI
Adenoviral Brain-Derived Neurotrophic Factor Induces Both Neostriatal and Olfactory Neuronal Recruitment from Endogenous Progenitor Cells in the Adult Forebrain
TL;DR: A single injection of adenoviral BDNF substantially augmented the recruitment of new neurons into both neurogenic and non-neurogenic sites in the adult rat brain, suggesting the intraventricular delivery of, and ependymal infection by, viral vectors encoding neurotrophic agents may be a feasible strategy for inducing neurogenesis from resident progenitor cells in theadult brain.
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TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Yun Li,Bryan W. Luikart,Shari G. Birnbaum,Jian Chen,Chang-Hyuk Kwon,Steven G. Kernie,Rhonda S Bassel-Duby,Luis F. Parada +7 more
TL;DR: This paper showed that mice lacking the receptor tyrosine kinase TrkB in hippocampal NPCs have impaired proliferation and neurogenesis and were behaviorally insensitive to antidepressive treatment in depression-and anxiety-like paradigms.
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Depolarization and cAMP Elevation Rapidly Recruit TrkB to the Plasma Membrane of CNS Neurons
Anke Meyer-Franke,George A Wilkinson,Alex Krüttgen,Minjie Hu,Elizabeth G. Munro,Martin G. Hanson,Louis F. Reichardt,Ben A. Barres +7 more
TL;DR: A novel mechanism for the rapid regulation of surface levels of the neurotrophin receptor TrkB is described, suggesting that activity and cAMP elevation rapidly recruit TrkB to the plasma membrane by translocation from intracellular stores.
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Neurotrophin regulation of cortical dendritic growth requires activity
A. Kimberley McAllister,A. Kimberley McAllister,Lawrence C Katz,Lawrence C Katz,Donald C. Lo +4 more
TL;DR: In ferret cortical brain slices, the interactions between activity and neurotrophins in regulating dendritic growth of layer 4 pyramidal neurons were examined, finding that inhibition of spontaneous electrical activity, synaptic transmission, or L-type calcium channels each prevented the otherwise dramatic increase in dendrite arborizations elicited by brain-derived neurotrophic factor.
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Neurotrophins are required for nerve growth during development.
TL;DR: A combination of function-blocking monoclonal antibodies to NGF, BDNF and NT-3 dramatically inhibited elongation of both sensory and motor axons in the limb bud, indicating that the growth of mixed nerves is dependent upon neurotrophins during development.