Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus
Mariana Carasatorre,Adrian Ochoa-Alvarez,Giovanna Velázquez-Campos,Carlos Lozano-Flores,Víctor Ramírez-Amaya,Sofía Y. Díaz-Cintra +5 more
TL;DR: The “catFISH” imaging method provided neurophysiological evidence that hippocampal pattern separation improved in animals treated as SC, and this improvement was even clearer in animals that experienced the WM training, strongly suggesting that structural synaptic plasticity in the hippocampus induced by the WM and SC experience is related to the improvement of spatial information processing inThe hippocampus.
Journal ArticleDOI
The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice.
Huiling Chen,Qing Huang,Qing Huang,Shunjia Zhang,Shunjia Zhang,Kaiqiang Hu,Wenxiang Xiong,Lingyun Xiao,Renhuai Cong,Qingfei Liu,Zhao Wang +10 more
TL;DR: A modified Chinese herbal formula using Panax ginseng, Angelica Sinensis, Polygala tenuifolia Willd, and Ziziphi spinosae Semen suggests that PAPZ has therapeutic effects in a mice depression model through increasing protein expression of BDNF and improving the anti-oxidation ability of the brain.
Journal ArticleDOI
Anti-apoptotic effects of BDNF-TrkB signaling in the treatment of hemorrhagic stroke
TL;DR: These comprehensive findings of the antiapoptotic effects of BDNF-TrkB signaling can contribute to the development of a novel therapeutic agent for patients with HS.
Journal ArticleDOI
Low BDNF levels in serum are associated with cognitive impairments in medication-naïve patients with current depressive episode in BD II and MDD.
Ziwei Teng,Lu Wang,Sujuan Li,Yuxi Tan,Yan Qiu,Chujun Wu,Kun Jin,Jindong Chen,Jing Huang,Hui Tang,Hui Xiang,Bolun Wang,Hui Yuan,Haishan Wu +13 more
TL;DR: In this article, the role of brain-derived neurotrophic factor (BDNF) in clinical and cognitive outcomes in medication-naive patients with Bipolar type II disorder (BD II) and Major depressive disorder (MDD) was investigated.
Journal ArticleDOI
A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength.
Patricia M. Horvath,Patricia M. Horvath,Natali L. Chanaday,Baris Alten,Ege T. Kavalali,Lisa M. Monteggia +5 more
TL;DR: In this paper, the authors studied the effects of the balance between inhibitory and excitatory spontaneous neurotransmission on brain-derived neurotrophic factor (BDNF) regulation and synaptic plasticity.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.