Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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Journal ArticleDOI
The effect of physical exercise on circulating brain‐derived neurotrophic factor in healthy subjects: A meta‐analysis of randomized controlled trials
TL;DR: To investigate how physical exercise would affect brain‐derived neurotrophic factor (BDNF) in randomized controlled trials (RCTs) of healthy subjects, a large number of subjects were randomly assigned to take part in PE trials.
Book ChapterDOI
The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications
TL;DR: The neurotrophic hypothesis of depression is revisited, examining evidence for, as well as against, the notion that reduced trophic support in key limbic brain regions contributes to the pathogenesis of depression, whereas enhanced Trophic factor signaling participates in the therapeutic actions of antidepressants.
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Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors
TL;DR: In this article , the role of the specific molecules expressed by these hypothalamic neurons in the regulation of innate behaviors that are essential to survival is highlighted, highlighting the challenges associated with targeting these pathways for weight loss therapy.
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Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment
TL;DR: The characterization of the spatiotemporal expression pattern of sortilin and SorCS2 in the developing murine nervous system is presented and will form the basis for hypotheses and study designs for unravelling the functions of sortILin and sorCS2 during the establishment of neuronal structures and connections.
Journal ArticleDOI
Saikosaponin-d impedes hippocampal neurogenesis and causes cognitive deficits by inhibiting the survival of neural stem/progenitor cells via neurotrophin receptor signaling in mice.
Tingting Qin,Ziqiao Yuan,Jiayu Yu,Xinxin Fu,Xueyang Deng,Qiang Fu,Zhanqiang Ma,Shiping Ma,Shiping Ma +8 more
TL;DR: The role of saikosaponin-d (SSd) in cognitive function and the mechanism by which SSd induced damage to hippocampal neurogenesis and NPCs were investigated in this paper.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.