Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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BDNF: a regulator of learning and memory processes with clinical potential
Tanja Brigadski,V. Leßmann +1 more
TL;DR: This review summarizes the current knowledge regarding the connection between BDNF, its role in synaptic plasticity and the role in brain.
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Definition of a Bidirectional Activity-Dependent Pathway Involving BDNF and Narp.
Abigail Mariga,Juliane Glaser,Leo Mathias,Desheng Xu,Meifang Xiao,Paul F. Worley,Ipe Ninan,Moses V. Chao +7 more
TL;DR: It is shown that Narp is a direct transcriptional target of brain-derived neurotrophic factor (BDNF), another highly regulated activity-dependent gene involved in synaptic plasticity, and that BDNF directly regulates Narp to mediate glutamatergic transmission and mossy fiber plasticity.
Journal ArticleDOI
Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling
TL;DR: It is shown that the other principal cell type, intrinsic interneurons, has a multistaged developmental plan that relies on retinal innervation, which indicates that signaling from the periphery guides the maturation of interneeurons and the establishment of inhibitory thalamic circuits.
Journal ArticleDOI
Neuroprotective effects of acetyl-l-carnitine on lipopolysaccharide-induced neuroinflammation in mice: Involvement of brain-derived neurotrophic factor
Filiz Kazak,Gul Fatma Yarim +1 more
TL;DR: ALCAR may be used as an optional neuroprotective and therapeutic agent to attenuate inflammatory damage in the CNS regarding BDNF, in a dose dependent manner.
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Multifaceted roles of BDNF and FGF2 in human striatal primordium development. An in vitro study
Erica Sarchielli,Mirca Marini,Stefano Ambrosini,Alessandro Peri,Benedetta Mazzanti,Pamela Pinzani,Emanuela Barletta,Lara Ballerini,Ferdinando Paternostro,Marco Paganini,Berardino Porfirio,Annamaria Morelli,Pasquale Gallina,Gabriella B. Vannelli +13 more
TL;DR: It is proposed that BDNF and FGF2 play an important autocrine-paracrine role during early striatum development in vivo and that their release by fetal striatal grafts may be relevant in the setting of HD cell therapy.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.