Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
Reads0
Chats0
TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
Citations
More filters
Journal ArticleDOI
Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome
TL;DR: In this article, the authors showed that delayed Rai1 deletion at 3 or 8 weeks of age had no effect on neurobehavioral functions but resulted in adult-onset obesity and decreased expression of brain-derived neurotrophic factor (Bdnf) in the hypothalamus.
Journal ArticleDOI
Elastase-2 Knockout Mice Display Anxiogenic- and Antidepressant-Like Phenotype: Putative Role for BDNF Metabolism in Prefrontal Cortex
Cassiano R.A.F. Diniz,Christiane Becari,Christiane Becari,Angelina Lesnikova,Caroline Biojone,Caroline Biojone,Maria Cristina O. Salgado,H C Salgado,Leonardo B. M. Resstel,Francisco Silveira Guimarães,Eero Castrén,Plinio C. Casarotto,Plinio C. Casarotto,Sâmia R.L. Joca,Sâmia R.L. Joca +14 more
TL;DR: In silico analysis indicates that ELA2 is putatively able to cleave BDNF, and incubation of the purified enzyme with BDNF led to the degradation of the latter.
Journal ArticleDOI
In utero Head Circumference is Associated with Childhood Allergy.
David P. Eviston,Anna Minasyan,Kristy Mann,Dianne E. Campbell,Dianne E. Campbell,Ralph Nanan +5 more
TL;DR: Smaller mid-gestational head circumference is associated with early childhood allergic disease, which suggests that fetal programing of allergic disease occurs before mid- gestation, and mediators such as brain-derived neurotrophic factor may be dysregulated early in utero in a milieu, which also predisposes to atopic disease.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor Val66Met polymorphism interacts with adolescent stress to alter hippocampal interneuron density and dendritic morphology in mice
Rachel Anne Hill,Rachel Anne Hill,Adrienne Mary Grech,Adrienne Mary Grech,Michael Notaras,Michael Notaras,Mauricio Sepulveda,Mauricio Sepulveda,Maarten van den Buuse,Maarten van den Buuse,Maarten van den Buuse +10 more
TL;DR: The BDNFVal66Met polymorphism significantly alters somatostatin and parvalbumin-positive interneuron cell development and dendrite morphology, and compounding effect of the Met/Met genotype and chronic adolescent CORT treatment on dendrites spine density is reported, indicating that adolescence is a sensitive period of risk for Val66Met carriers.
Journal ArticleDOI
Increased Anxiety-like Behaviors in Adgra1−/− Male But Not Female Mice are Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K/AKT/GSK-3β and MEK/ERK Pathways
Xiaohong Zhang,Chunling Shen,Xiyi Wang,Wenfeng Xiong,X. Shang,Lingyun Tang,Hongbin Zhang,Ying-Han Wan,Youbing Wu,Jian Fei,Qi-Zhong Yi,Zhugang Wang +11 more
TL;DR: In this paper , the authors comprehensively analyzed the potential role of ADGRA1 in the neurobehaviors of mice by comparing AdgRA1−/− and their wild-type (wt) littermates.
References
More filters
Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
Journal ArticleDOI
The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
Journal ArticleDOI
Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.