Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
Citations
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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Christiane D. Wrann,James P. White,John Salogiannnis,Dina Laznik-Bogoslavski,Jun Wu,Di Ma,Jiandie D. Lin,Michael E. Greenberg,Bruce M. Spiegelman +8 more
TL;DR: It is shown that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice.
Journal ArticleDOI
The Central Nervous System and the Gut Microbiome
TL;DR: The biological intersection of neurodevelopment and the microbiome is discussed and the hypothesis that gut bacteria are integral contributors to development and function of the nervous system and the balance between mental health and disease is explored.
Journal ArticleDOI
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.
Przemysław Kowiański,Grazyna Lietzau,Ewelina Czuba,Monika Waśkow,Aleksandra Steliga,Janusz Moryś +5 more
TL;DR: The importance of BDNF for future studies aimed at disclosing mechanisms of activation of signaling pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.
Journal ArticleDOI
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
Journal ArticleDOI
BDNF - a key transducer of antidepressant effects.
Carl Björkholm,Lisa M. Monteggia +1 more
TL;DR: Current data suggests that conventional antidepressants and ketamine mediate their antidepressant-like effects by increasing BDNF in forebrain regions, in particular the hippocampus, making BDNF an essential determinant of antidepressant efficacy.
References
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Journal ArticleDOI
Quantal transmitter secretion from myocytes loaded with acetylcholine.
Yang Dan,Mu-ming Poo +1 more
TL;DR: It is reported that when acetylcholine (ACh) is loaded into an isolated Xenopus myocyte, there is spontaneous quantal release of ACh from the myocyte which results in activation of its own surface ACh channels and the appearance of membrane currents resembling miniature endplate currents.
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GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses.
Hervé Fiorentino,Nicola Kuczewski,Diabe Diabira,Nadine Ferrand,Menelas N. Pangalos,Christophe Porcher,Jean-Luc Gaiarsa +6 more
TL;DR: A novel mechanism by which endogenous GABA selectively regulates the development of GABAergic synapses in the developing brain is demonstrated by using whole-cell patch-clamp recordings and time-lapse fluorescence imaging on cultured hippocampal neurons expressing GFP-tagged brain-derived neurotrophic factor.
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Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5.
TL;DR: The results suggested that early in development BDNF and NT4/5 probably accelerate dendritogenesis in an autocrine fashion and branch formation was advanced towards the adult pattern in pyramidal cells and interneurons.
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Axonal and dendritic synaptotagmin isoforms revealed by a pHluorin-syt functional screen.
Camin Dean,F. Mark Dunning,Huisheng Liu,Ewa Bomba-Warczak,Henrik Martens,Vinita Bharat,Saheeb Ahmed,Edwin R. Chapman +7 more
TL;DR: Syt-pHluorin reporters are used to show that only two syts are on synaptic vesicles, whereas other isoforms are selectively targeted to dendrites, axons, or both axons and dendrite, where they undergo exocytosis and endocytoses with distinct kinetics.
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Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels.
TL;DR: The results demonstrate a requirement for Rab3A and may reveal a temporal distinction between presynaptic and postsynaptic mechanisms of BDNF-induced synaptic plasticity associated with learning and memory.