Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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Synaptic regulation of affective behaviors; role of BDNF
TL;DR: Understanding how BDNF modulates synapses in neural circuits relevant to affective behaviors, particularly the medial prefrontal cortical (mPFC)-hippocampus-amygdala pathway, and its interaction with development, sex, and environmental risk factors might shed light on potential therapeutic targets for affective disorders.
Journal ArticleDOI
Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging
Sandra Giovanoli,Tina Notter,Juliet Richetto,Marie A. Labouesse,Stéphanie Vuillermot,Marco A. Riva,Urs Meyer,Urs Meyer +7 more
TL;DR: It is concluded that poly(I:C)-based prenatal immune activation models are reliable in their effectiveness to induce (hippocampal) neuropathology across aging, but they appear unsuited for studying the role of chronic systemic or central inflammation in brain aging.
Journal ArticleDOI
TrkB dependent adult hippocampal progenitor differentiation mediates sustained ketamine antidepressant response
Zhenzhong Ma,Tong Zang,Shari G. Birnbaum,Zilai Wang,Zilai Wang,Jane E. Johnson,Chun Li Zhang,Luis F. Parada,Luis F. Parada +8 more
TL;DR: Ketamine can promote neuronal differentiation via TrkB-ERK activation in mice and the sustained behavioral effect is attenuated when adult neurogenesis is blocked, but extended when it is enhanced.
Journal ArticleDOI
D-serine as a gliotransmitter and its roles in brain development and disease
TL;DR: The evidence that D-serine is actively released by glial cells is considered and the studies that have implicated D-Serine as a critical player involved in regulating NMDAR-mediated synaptic transmission and neuronal migration during development are examined.
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Shaping neurons: Long and short range effects of mature and proBDNF signalling upon neuronal structure
Katrin Deinhardt,Moses V. Chao +1 more
TL;DR: The evidence that BDNF modulates neural circuit formation in vivo both within the central and peripheral nervous systems, through the control of neuronal morphology is summarized.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.