Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
Citations
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Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Christiane D. Wrann,James P. White,John Salogiannnis,Dina Laznik-Bogoslavski,Jun Wu,Di Ma,Jiandie D. Lin,Michael E. Greenberg,Bruce M. Spiegelman +8 more
TL;DR: It is shown that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance exercise in the hippocampus of mice.
Journal ArticleDOI
The Central Nervous System and the Gut Microbiome
TL;DR: The biological intersection of neurodevelopment and the microbiome is discussed and the hypothesis that gut bacteria are integral contributors to development and function of the nervous system and the balance between mental health and disease is explored.
Journal ArticleDOI
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.
Przemysław Kowiański,Grazyna Lietzau,Ewelina Czuba,Monika Waśkow,Aleksandra Steliga,Janusz Moryś +5 more
TL;DR: The importance of BDNF for future studies aimed at disclosing mechanisms of activation of signaling pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.
Journal ArticleDOI
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
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BDNF - a key transducer of antidepressant effects.
Carl Björkholm,Lisa M. Monteggia +1 more
TL;DR: Current data suggests that conventional antidepressants and ketamine mediate their antidepressant-like effects by increasing BDNF in forebrain regions, in particular the hippocampus, making BDNF an essential determinant of antidepressant efficacy.
References
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Journal ArticleDOI
Translational control of localized mRNAs: restricting protein synthesis in space and time
Florence Besse,Anne Ephrussi +1 more
TL;DR: Subcellular targeting of mRNAs has emerged as a major mechanism for cells to establish functionally distinct compartments and structures and the inactivation of repressors, either by pre-localized proteins or in response to conserved signalling pathways, triggers local protein synthesis.
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Can molecules explain long-term potentiation?
Joshua R. Sanes,Jeff W. Lichtman +1 more
TL;DR: The difficulties of providing molecular explanations for cellular neurobiological phenomena are discussed and the importance of consensus on their underlying molecular mechanisms is highlighted.
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Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
TL;DR: It is found that the TRPC3 protein was highly enriched in neurons of the central nervous system (CNS) and paralleled that of the neurotrophin receptor TrkB, leading to activation of TrkB and PLC leads to aTRPC3-dependent cation influx in CNS neurons.
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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Tomoya Matsumoto,Stefanie Rauskolb,Martin Polack,Johannes Klose,Roland Kolbeck,Martin Korte,Yves-Alain Barde +6 more
TL;DR: The biochemistry of endogenous BDNF in mouse neurons is examined using sensitive reagents and it is found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.
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A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition
Elizabeth J. Hong,Alejandra E. McCord,Alejandra E. McCord,Michael E. Greenberg,Michael E. Greenberg +4 more
TL;DR: A specific requirement for activity-dependent Bdnf expression in the development of inhibition in the cortex is indicated and it is demonstrated that the activation of gene expression in response to experience-driven neuronal activity has important biological consequences in the nervous system.