Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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Serotonergic projections to lumbar levels and its plasticity following spinal cord injury
TL;DR: This 5-HT innervation pattern in the lumbar cord provides anatomical evidence that serotonergic fibers establish direct connections withlumbar motoneurons, which offers a solid foundation that enhancing the plasticity ofserotonergic pathway following SCI may facilitate locomotor functional recovery.
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Prolongation of Relaxation Time in Extraocular Muscles With Brain Derived Neurotrophic Factor in Adult Rabbit
TL;DR: Short-term treatment with BDNF significantly prolonged the duration and rate of relaxation time and increased expression of both slow-twitch and slow-tonic myosin-expressing myofibers without changes in neuromuscular junctions or SERCA expression.
Journal ArticleDOI
Reprogramming of Oncogene Expression in Gingival Mesenchymal Stem Cells Following Long-Term Culture In Vitro
Agnese Gugliandolo,Thangavelu Soundara Rajan,Domenico Scionti,Francesca Diomede,Placido Bramanti,Emanuela Mazzon,Oriana Trubiani +6 more
TL;DR: It is found that the expression of 22 oncogenes was abolished in gingival MSCs at Passage number 41 compared to those at passage number 10, and this may indicate a greater safety of high number passage M SCs.
Journal ArticleDOI
Neonatal hypoxic-ischemic encephalopathy reduces c-Fos activation in the rat hippocampus: evidence of a long-lasting effect.
Andressa de Souza,Jairo Alberto Dussán-Sarria,Liciane Fernandes Medeiros,Ana Cláudia de Souza,Carla de Oliveira,Vanessa Leal Scarabelot,Lauren Naomi Adachi,Elisa C. Winkelmann-Duarte,Bárbara Beatriz Philippi‐Martins,Carlos Alexandre Netto,Wolnei Caumo,Iraci Lucena da Silva Torres +11 more
TL;DR: In this article, the effect of neonatal hypoxic-ischemic encephalopathy (HIE) on maturation of nociceptive pathways has been sparsely explored.
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Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults - A Randomized Controlled Feasibility Study.
Andreas Becke,Andreas Becke,Patrick Müller,Milos Dordevic,Volkmar Lessmann,Tanja Brigadski,Tanja Brigadski,Notger G. Müller +7 more
TL;DR: The present data suggest that hypoxic treatment using intensive IHT can reduce BDNF plasma levels for at least 2 weeks, indicating that the daily application of hypoxic air is too frequent for the aimed physiological response, namely, an increase in BDNF levels.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.