Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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Neuronal excitability and spontaneous synaptic transmission in the entorhinal cortex of BDNF heterozygous mice.
TL;DR: The findings suggest that reductions in concentrations of BDNF results in altered status of excitability and excitation/inhibition imbalance, however, these differences observed in BDNF (+/-) seem to have opposing effects on neuronal activity.
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No association between BDNF Val66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population.
Hidehiro Umehara,Shusuke Numata,Makoto Kinoshita,Shinya Watanabe,Shutaro Nakaaki,Satsuki Sumitani,Tetsuro Ohmori +6 more
TL;DR: The results suggest that the BDNF Val66Met polymorphism may not be associated as a risk factor for developing OCD or with therapeutic response in patients with OCD in the Japanese population.
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The impact of maternal high-fat diet on offspring neurodevelopment
TL;DR: Current findings from rodent models and from human studies are reviewed to reveal potential mechanisms by which a maternal high-fat diet interferes with the neurodevelopment of the offspring.
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Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation
Kazuo Furukawa,Ichiro Fuse,Yuriko Iwakura,Hidekazu Sotoyama,Osamu Hanyu,Hiroyuki Nawa,Hirohito Sone,Nobuyuki Takei +7 more
TL;DR: Considering the toxic action of AGEs and the protective roles of BDNF, it can be hypothesized that AGE-induced BDNF release is a biological defense system in the early phase of diabetes.
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Glucocorticoid affects dendritic transport of BDNF-containing vesicles.
Naoki Adachi,Tadahiro Numakawa,Shingo Nakajima,Masashi Fukuoka,Haruki Odaka,Yusuke Katanuma,Yoshiko Ooshima,Hirohiko Hohjoh,Hiroshi Kunugi +8 more
TL;DR: Examination of the effect of dexamethasone (DEX), a synthetic glucocorticoid, on BDNF-containing vesicle transport found that DEX decreased the proportion of stationary vesicles and increased velocity of the microtubule-based vesicular transport in dendrites of cortical neurons.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
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Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.