Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
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TLDR
Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.Abstract:
Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 4--has emerged as a key regulator of neural circuit development and function. The expression, secretion and actions of BDNF are directly controlled by neural activity, and secreted BDNF is capable of mediating many activity-dependent processes in the mammalian brain, including neuronal differentiation and growth, synapse formation and plasticity, and higher cognitive functions. This Review summarizes some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits. The focus of the article is on BDNF, as this is the most widely expressed and studied neurotrophin in the mammalian brain.read more
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BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation
TL;DR: The results suggest that the BDNF/SHP2/GluN2B-NMDA signaling cascade plays a vital role in the development of central sensitization and neuropathic pain after peripheral nerve injury.
Journal ArticleDOI
Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus
TL;DR: The data suggest that methamphetamine self-administration initiates distinct allostatic changes in hippocampal subregions that may contribute to the altered synaptic activity in the hippocampus, which may underlie enhanced negative affective symptoms and perpetuation of the addiction cycle.
Journal ArticleDOI
Effects of a Home-Based Family-Centred Early Habilitation Program on Neurobehavioural Outcomes of Very Preterm Born Infants: A Retrospective Cohort Study
Michela Poggioli,Fabrizio Minichilli,Tiziana Bononi,Pasquina Meghi,Paolo Andre,Alessandra Crecchi,Bruno Rossi,Maria Chiara Carboncini,Alberto Ottolini,Luca Bonfiglio +9 more
TL;DR: In conclusion, a timely updated environment suitable to the infant's developmental needs could provide the best substrate where the parent-infant relationship can be practised with the ultimate goal of achieving further developmental steps.
Journal ArticleDOI
Pool size estimations for dense-core vesicles in mammalian CNS neurons
Claudia M. Persoon,Alessandro Moro,Joris Paul Nassal,Margherita Farina,Jurjen H. Broeke,Swati Arora,Natalia Domínguez,Jan R.T. van Weering,Ruud F. Toonen,Matthijs Verhage +9 more
TL;DR: Mammalian CNS neurons contain a large pool of DCVs of which only a small fraction can fuse, preferentially at axons, here quantified DCV pool sizes in three types of mammalian CNS neurons in vitro and in vivo.
Journal ArticleDOI
Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures.
Nuno Jorge Lamas,Bethany L. Johnson-Kerner,Laurent Roybon,Yoon A. Kim,Alejandro Garcia-Diaz,Hynek Wichterle,Christopher E. Henderson +6 more
TL;DR: In this article, a small-molecule collection of human stem cells derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) was used to optimize a robust survival assay and characterize their response to different neurotrophic factors.
References
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Journal ArticleDOI
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Michael F. Egan,Masami Kojima,Masami Kojima,Joseph H. Callicott,Terry E. Goldberg,Bhaskar Kolachana,Alessandro Bertolino,Eugene Zaitsev,Bert Gold,David Goldman,Michael Dean,Bai Lu,Daniel R. Weinberger +12 more
TL;DR: A role is demonstrated for BDNF and its val/met polymorphism in human memory and hippocampal function and it is suggested val/ met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF.
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The nerve growth factor 35 years later
TL;DR: The field of experimental embryology, which had been enthusiastically acclaimed in the mid-thirties, suffered from a sharp decrease in the enthusiasm that had inflamed the pioneers in this field, ever since R. G. Harrison delivered his celebrated lecture at the Royal Society in London in 1935.
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Synaptic Activity and the Construction of Cortical Circuits
Lawrence C. Katz,Carla J. Shatz +1 more
TL;DR: The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Journal ArticleDOI
Neurotrophins and their receptors: a convergence point for many signalling pathways.
TL;DR: Recent findings that neurotrophins, in addition to promoting survival and differentiation, exert various effects through surprising interactions with other receptors and ion channels are reviewed.
Journal ArticleDOI
Physiology of the neurotrophins
Gary R. Lewin,Yves-Alain Barde +1 more
TL;DR: Rapid actions of neurotrophin-3 on synaptic efficacy, as well as the regulation of their mRNAs by electrical activity, suggest that neurotrophins might play important roles in regulating neuronal connectivity in the developing and in the adult central nervous system.